Optimizing the deprotection of the amine protecting p-methoxyphenyl group in an automated microreactor platform

K. Koch, B.J.A. van Weerdenburg, J.M.M. Verkade, P.J. Nieuwland, F.P.J.T. Rutjes, J.C.M. Hest, van

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Abstract

Three factors (temperature, stoichiometry and reaction temperature) were investigated in continuous flow microreactors in an automated fashion for optimization of the removal of the p- methoxyphenyl (PMP) protecting group, thereby consuming only minute amounts of substrate (0.2 mg/sample). The optimal reaction conditions were also applied to a larger microreactor system, in which the corresponding free amine was obtained at a preparative scale.

Original languageEnglish
Pages (from-to)1003-1006
Number of pages4
JournalOrganic Process Research & Development
Volume13
Issue number5
DOIs
Publication statusPublished - 18 Sep 2009
Externally publishedYes

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