Abstract
Three factors (temperature, stoichiometry and reaction temperature) were investigated in continuous flow microreactors in an automated fashion for optimization of the removal of the p- methoxyphenyl (PMP) protecting group, thereby consuming only minute amounts of substrate (0.2 mg/sample). The optimal reaction conditions were also applied to a larger microreactor system, in which the corresponding free amine was obtained at a preparative scale.
Original language | English |
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Pages (from-to) | 1003-1006 |
Number of pages | 4 |
Journal | Organic Process Research & Development |
Volume | 13 |
Issue number | 5 |
DOIs | |
Publication status | Published - 18 Sept 2009 |
Externally published | Yes |