Optimization of temperature programming in gas chromatography with respect to separation time. II. Optimization of the individual temperature programme substrategies

The temperature programme optimization substrategies for a mixture with non-intersecting retention time approximation functions are described. For mixtures of compounds whose elution functions intersect, the determination of strategies for possible solutions and of the corresponding substrategies for temperature programme optimization is derived. Heuristic methods for the minimization of the retention times of the most difficult to separate component pairs are presented. Further, the calculation of retention times and peak widths for optimization purposes is discussed.