Optimisation of the preparation and isolation of 5-amino-2,4,6-triiodoisophthalic acid dichloride

H.J.M. Gijsen, H.C.C.K. Bakel, van, W. Zwaan, L.A. Hulshof

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

A scaleable process for the chlorination of 5-amino-2,4,6-triiodoisophthalic acid to the corresponding acid chloride, a building block for the synthesis of iodinated X-ray contrast agents, has been developed. Two dimeric byproducts have been isolated and assigned structures consistent with an amide and an anhydride. Hydrolysis of the N-sulfinyl intermediate and simultaneous crystallisation of the phthalic acid chloride have been optimised by applying fractional factorial design.
Original languageEnglish
Pages (from-to)38-43
Number of pages7
JournalOrganic Process Research & Development
Volume3
Issue number1
DOIs
Publication statusPublished - 1999

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