TY - JOUR
T1 - Optimisation of Pt sensitivity in PIXE analysis of thin biological samples
AU - Tiourina, T.B.
AU - Mutsaers, P.H.A.
AU - Voigt, de, M.J.A.
PY - 1998
Y1 - 1998
N2 - To obtain Pt concentration distributions in tumor biopsies, micro-PIXE is used. The Limit of Detection (LOD) for Pt is determined by the background production cross section together with the production cross section for the Pt–L lines. Both are functions of the type and energy of the projectile. In order to optimise the experimental conditions, the proton energy is varied from 2.5 to 5 MeV and the corresponding X-ray spectra are analysed. The optimum LOD is about 1 µg/g for a sample thickness of 1 mg/cm2 and a total charge of 100 µC. A study is performed to investigate the possibility of elemental analysis by means of a excitation. The corresponding LOD is 6 µg/g with 200 µC charge (He++ was used). For a excitation, sample damage limits the beam current and, thus, causes a tremendous increase in the measurement time.
AB - To obtain Pt concentration distributions in tumor biopsies, micro-PIXE is used. The Limit of Detection (LOD) for Pt is determined by the background production cross section together with the production cross section for the Pt–L lines. Both are functions of the type and energy of the projectile. In order to optimise the experimental conditions, the proton energy is varied from 2.5 to 5 MeV and the corresponding X-ray spectra are analysed. The optimum LOD is about 1 µg/g for a sample thickness of 1 mg/cm2 and a total charge of 100 µC. A study is performed to investigate the possibility of elemental analysis by means of a excitation. The corresponding LOD is 6 µg/g with 200 µC charge (He++ was used). For a excitation, sample damage limits the beam current and, thus, causes a tremendous increase in the measurement time.
U2 - 10.1016/S0168-583X(97)01003-3
DO - 10.1016/S0168-583X(97)01003-3
M3 - Article
SN - 0168-583X
VL - 139
SP - 186
EP - 191
JO - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
JF - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
IS - 1-4
ER -