Optimal cell transport in straight channels and networks

Alexander Farutin, Zaiyi Shen, Gael Prado, Vassanti Audemar, Hamid Ez-Zahraouy, Abdelilah Benyoussef, Benoit Polack, Jens Harting, Petia M. Vlahovska, Thomas Podgorski, Gwennou Coupier, Chaouqi Misbah

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    1 Citation (Scopus)
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    Abstract

    Flux of rigid or soft particles (such as drops, vesicles, red blood cells, etc.) in a channel is a complex function of particle concentration, which depends on the details of induced dissipation and suspension structure due to hydrodynamic interactions with walls or between neighboring particles. Through two-dimensional and three-dimensional simulations and a simple model that reveals the contribution of the main characteristics of the flowing suspension, we discuss the existence of an optimal volume fraction for cell transport and its dependence on the cell mechanical properties. The example of blood is explored in detail, by adopting the commonly used modeling of red blood cells dynamics. We highlight the complexity of optimization at the level of a network, due to the antagonist evolution of local volume fraction and optimal volume fraction with the channels diameter. In the case of the blood network, the most recent results on the size evolution of vessels along the circulatory network of healthy organs suggest that the red blood cell volume fraction (hematocrit) of healthy subjects is close to optimality, as far as transport only is concerned. However, the hematocrit value of patients suffering from diverse red blood cel pathologies may strongly deviate from optimality.

    Original languageEnglish
    Article number103603
    Number of pages18
    JournalPhysical Review Fluids
    Volume3
    Issue number10
    DOIs
    Publication statusPublished - 1 Oct 2018

    Cite this

    Farutin, A., Shen, Z., Prado, G., Audemar, V., Ez-Zahraouy, H., Benyoussef, A., ... Misbah, C. (2018). Optimal cell transport in straight channels and networks. Physical Review Fluids, 3(10), [103603 ]. https://doi.org/10.1103/PhysRevFluids.3.103603
    Farutin, Alexander ; Shen, Zaiyi ; Prado, Gael ; Audemar, Vassanti ; Ez-Zahraouy, Hamid ; Benyoussef, Abdelilah ; Polack, Benoit ; Harting, Jens ; Vlahovska, Petia M. ; Podgorski, Thomas ; Coupier, Gwennou ; Misbah, Chaouqi. / Optimal cell transport in straight channels and networks. In: Physical Review Fluids. 2018 ; Vol. 3, No. 10.
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    abstract = "Flux of rigid or soft particles (such as drops, vesicles, red blood cells, etc.) in a channel is a complex function of particle concentration, which depends on the details of induced dissipation and suspension structure due to hydrodynamic interactions with walls or between neighboring particles. Through two-dimensional and three-dimensional simulations and a simple model that reveals the contribution of the main characteristics of the flowing suspension, we discuss the existence of an optimal volume fraction for cell transport and its dependence on the cell mechanical properties. The example of blood is explored in detail, by adopting the commonly used modeling of red blood cells dynamics. We highlight the complexity of optimization at the level of a network, due to the antagonist evolution of local volume fraction and optimal volume fraction with the channels diameter. In the case of the blood network, the most recent results on the size evolution of vessels along the circulatory network of healthy organs suggest that the red blood cell volume fraction (hematocrit) of healthy subjects is close to optimality, as far as transport only is concerned. However, the hematocrit value of patients suffering from diverse red blood cel pathologies may strongly deviate from optimality.",
    author = "Alexander Farutin and Zaiyi Shen and Gael Prado and Vassanti Audemar and Hamid Ez-Zahraouy and Abdelilah Benyoussef and Benoit Polack and Jens Harting and Vlahovska, {Petia M.} and Thomas Podgorski and Gwennou Coupier and Chaouqi Misbah",
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    Farutin, A, Shen, Z, Prado, G, Audemar, V, Ez-Zahraouy, H, Benyoussef, A, Polack, B, Harting, J, Vlahovska, PM, Podgorski, T, Coupier, G & Misbah, C 2018, 'Optimal cell transport in straight channels and networks', Physical Review Fluids, vol. 3, no. 10, 103603 . https://doi.org/10.1103/PhysRevFluids.3.103603

    Optimal cell transport in straight channels and networks. / Farutin, Alexander; Shen, Zaiyi; Prado, Gael; Audemar, Vassanti; Ez-Zahraouy, Hamid; Benyoussef, Abdelilah; Polack, Benoit; Harting, Jens; Vlahovska, Petia M.; Podgorski, Thomas; Coupier, Gwennou; Misbah, Chaouqi.

    In: Physical Review Fluids, Vol. 3, No. 10, 103603 , 01.10.2018.

    Research output: Contribution to journalArticleAcademicpeer-review

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    AU - Benyoussef, Abdelilah

    AU - Polack, Benoit

    AU - Harting, Jens

    AU - Vlahovska, Petia M.

    AU - Podgorski, Thomas

    AU - Coupier, Gwennou

    AU - Misbah, Chaouqi

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    Farutin A, Shen Z, Prado G, Audemar V, Ez-Zahraouy H, Benyoussef A et al. Optimal cell transport in straight channels and networks. Physical Review Fluids. 2018 Oct 1;3(10). 103603 . https://doi.org/10.1103/PhysRevFluids.3.103603