Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

L. Prinzen, R.J.H.M. Miserus, A. Dirksen, T.M. Hackeng, N.M. Deckers, N.J. Bitsch, R.T.A. Megens, K. Douma, J.W. Heemskerk, M.E. Kooi, P.M. Frederik, D.W. Slaaf, M. Zandvoort, van, C.P.M. Reutelingsperger

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Abstract

A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r1) of 3000-4500 mM-1 s-1 per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies. © 2007 American Chemical Society.
Original languageEnglish
Pages (from-to)93-100
JournalNano Letters
Volume7
Issue number1
DOIs
Publication statusPublished - 2007

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