Abstract
A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r1) of 3000-4500 mM-1 s-1 per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies. © 2007 American Chemical Society.
Original language | English |
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Pages (from-to) | 93-100 |
Journal | Nano Letters |
Volume | 7 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2007 |
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Dive into the research topics of 'Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots'. Together they form a unique fingerprint.Equipment
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Center for Multiscale Electron Microscopy (CMEM)
Heiner Friedrich (Manager), Rick Joosten (Education/research officer), Pauline Schmit (Education/research officer), Ingeborg Schreur - Piet (Other) & Anne Spoelstra (Education/research officer)
Physical ChemistryFacility/equipment: Research lab