Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

L. Prinzen; R.J.H.M. Miserus; A. Dirksen; T.M. Hackeng; N.M. Deckers; N.J. Bitsch; R.T.A. Megens; K. Douma; J.W. Heemskerk; M.E. Kooi; P.M. Frederik; D.W. Slaaf; M. Zandvoort, van; C.P.M. Reutelingsperger

doi:10.1021/nl062226r

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

L. Prinzen, R.J.H.M. Miserus, A. Dirksen, T.M. Hackeng, N.M. Deckers, N.J. Bitsch, R.T.A. Megens, K. Douma, J.W. Heemskerk, M.E. Kooi, P.M. Frederik, D.W. Slaaf, M. Zandvoort, van, C.P.M. Reutelingsperger

Biomedical Engineering

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Abstract

A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r1) of 3000-4500 mM-1 s-1 per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies. © 2007 American Chemical Society.

Original language	English
Pages (from-to)	93-100
Journal	Nano Letters
Volume	7
Issue number	1
DOIs	https://doi.org/10.1021/nl062226r
Publication status	Published - 2007

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Prinzen, L., Miserus, R. J. H. M., Dirksen, A., Hackeng, T. M., Deckers, N. M., Bitsch, N. J., Megens, R. T. A., Douma, K., Heemskerk, J. W., Kooi, M. E., Frederik, P. M., Slaaf, D. W., Zandvoort, van, M., & Reutelingsperger, C. P. M. (2007). Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots. Nano Letters, 7(1), 93-100. https://doi.org/10.1021/nl062226r

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title = "Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots",

abstract = "A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r1) of 3000-4500 mM-1 s-1 per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies. {\textcopyright} 2007 American Chemical Society.",

author = "L. Prinzen and R.J.H.M. Miserus and A. Dirksen and T.M. Hackeng and N.M. Deckers and N.J. Bitsch and R.T.A. Megens and K. Douma and J.W. Heemskerk and M.E. Kooi and P.M. Frederik and D.W. Slaaf and {Zandvoort, van}, M. and C.P.M. Reutelingsperger",

year = "2007",

doi = "10.1021/nl062226r",

language = "English",

volume = "7",

pages = "93--100",

journal = "Nano Letters",

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publisher = "American Chemical Society",

number = "1",

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Prinzen, L, Miserus, RJHM, Dirksen, A, Hackeng, TM, Deckers, NM, Bitsch, NJ, Megens, RTA, Douma, K, Heemskerk, JW, Kooi, ME, Frederik, PM, Slaaf, DW, Zandvoort, van, M & Reutelingsperger, CPM 2007, 'Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots', Nano Letters, vol. 7, no. 1, pp. 93-100. https://doi.org/10.1021/nl062226r

TY - JOUR

T1 - Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

AU - Prinzen, L.

AU - Miserus, R.J.H.M.

AU - Dirksen, A.

AU - Hackeng, T.M.

AU - Deckers, N.M.

AU - Bitsch, N.J.

AU - Megens, R.T.A.

AU - Douma, K.

AU - Heemskerk, J.W.

AU - Kooi, M.E.

AU - Frederik, P.M.

AU - Slaaf, D.W.

AU - Zandvoort, van, M.

AU - Reutelingsperger, C.P.M.

PY - 2007

Y1 - 2007

N2 - A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r1) of 3000-4500 mM-1 s-1 per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies. © 2007 American Chemical Society.

AB - A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r1) of 3000-4500 mM-1 s-1 per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies. © 2007 American Chemical Society.

U2 - 10.1021/nl062226r

DO - 10.1021/nl062226r

M3 - Article

C2 - 17212446

SN - 1530-6984

VL - 7

SP - 93

EP - 100

JO - Nano Letters

JF - Nano Letters

IS - 1

ER -

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

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