TY - JOUR
T1 - Open-source image analysis tool for the identification and quantification of cortical interruptions and bone erosions in high-resolution peripheral quantitative computed tomography images of patients with rheumatoid arthritis
AU - Zhao, Mingjie
AU - Tse, Justin J.
AU - Kuczynski, Michael T.
AU - Brunet, Scott C.
AU - Yan, Ryan
AU - Engelke, Klaus
AU - Peters, Michiel
AU - van den Bergh, Joop P.
AU - van Rietbergen, Bert
AU - Stok, Kathryn S.
AU - Barnabe, Cheryl
AU - Pauchard, Yves
AU - Manske, Sarah L.
N1 - Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Identification of bone erosions and quantification of erosion volume is important for rheumatoid arthritis diagnosis, and can add important information to evaluate disease progression and treatment effects. High-resolution peripheral quantitative computed tomography (HR-pQCT) is well suited for this purpose, however analysis methods are not widely available. The purpose of this study was to develop an open-source software tool for the identification and quantification of bone erosions using images acquired by HR-pQCT. The collection of modules, Bone Analysis Modules (BAM) - Erosion, implements previously published erosion analysis techniques as modules in 3D Slicer, an open-source image processing and visualization tool. BAM includes a module to automatically identify cortical interruptions, from which erosions are manually selected, and a hybrid module that combines morphological and level set operations to quantify the volume of bone erosions. HR-pQCT images of the second and third metacarpophalangeal (MCP) joints were acquired in patients with RA (XtremeCT, n = 14, XtremeCTII, n = 22). The number of cortical interruptions detected by BAM-Erosion agreed strongly with the previously published cortical interruption detection algorithm for both XtremeCT (r
2 = 0.85) and XtremeCTII (r
2 = 0.87). Erosion volume assessment by BAM-Erosion agreed strongly (r
2 = 0.95) with the Medical Image Analysis Framework. BAM-Erosion provides an open-source erosion analysis tool that produces comparable results to previously published algorithms, with improved options for visualization. The strength of the tool is that it implements multiple image processing algorithms for erosion analysis on a single, widely available, open-source platform that can accommodate future updates.
AB - Identification of bone erosions and quantification of erosion volume is important for rheumatoid arthritis diagnosis, and can add important information to evaluate disease progression and treatment effects. High-resolution peripheral quantitative computed tomography (HR-pQCT) is well suited for this purpose, however analysis methods are not widely available. The purpose of this study was to develop an open-source software tool for the identification and quantification of bone erosions using images acquired by HR-pQCT. The collection of modules, Bone Analysis Modules (BAM) - Erosion, implements previously published erosion analysis techniques as modules in 3D Slicer, an open-source image processing and visualization tool. BAM includes a module to automatically identify cortical interruptions, from which erosions are manually selected, and a hybrid module that combines morphological and level set operations to quantify the volume of bone erosions. HR-pQCT images of the second and third metacarpophalangeal (MCP) joints were acquired in patients with RA (XtremeCT, n = 14, XtremeCTII, n = 22). The number of cortical interruptions detected by BAM-Erosion agreed strongly with the previously published cortical interruption detection algorithm for both XtremeCT (r
2 = 0.85) and XtremeCTII (r
2 = 0.87). Erosion volume assessment by BAM-Erosion agreed strongly (r
2 = 0.95) with the Medical Image Analysis Framework. BAM-Erosion provides an open-source erosion analysis tool that produces comparable results to previously published algorithms, with improved options for visualization. The strength of the tool is that it implements multiple image processing algorithms for erosion analysis on a single, widely available, open-source platform that can accommodate future updates.
KW - Bone erosions
KW - Cortical interruptions
KW - High-resolution peripheral quantitative computed tomography
KW - Image processing
KW - Metacarpophalangeal joint
KW - Open source software
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=85139021875&partnerID=8YFLogxK
U2 - 10.1016/j.bone.2022.116571
DO - 10.1016/j.bone.2022.116571
M3 - Article
C2 - 36174928
SN - 8756-3282
VL - 165
JO - Bone
JF - Bone
M1 - 116571
ER -