Abstract
Continuous flow chemistry holds great potential for the production of biologically relevant molecules. Herein, we present an approach for the continuous synthesis of cannabidiol and tetrahydrocannabinol in a one-flow system. The designed route consists of a reaction cascade involving Friedel-Crafts alkylation, subsequent ring opening and cyclisation in up to 45% yield. The reactions were successfully performed using both hetero- and homogeneous Lewis acids in continuous flow and provide yields that are similar to comparable batch processes. Graphical abstract: [Figure not available: see fulltext.]
Original language | English |
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Pages (from-to) | 99-105 |
Number of pages | 7 |
Journal | Journal of Flow Chemistry |
Volume | 11 |
Issue number | 2 |
Early online date | 4 Jan 2021 |
DOIs | |
Publication status | Published - Jun 2021 |
Keywords
- Cannabinoids
- Flow chemistry
- Heterocycles
- Heterogeneous Lewis acid catalysis