On the separation of 99mTcO4-, 99mTc-DTPA and 99mTc-citrate as marker species for the determination of Tc chemical forms in plant material using capillary zone electrophoresis

G.C. Krijger, H.A. Claessens, H.Th. Wolterbeek

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

The present paper addresses the potential use of capillary zone electrophoresis (CZE) as an anal. tool in 99Tc speciation studies. To optimize sampling, storage and anal. procedures, the three marker compds. 99mTcO4-, 99mTc-DTPA and 99mTc-citrate were synthesized and used in test-measurements with CZE. The results underline the superior sepn. power of the CZE technique, and indicate good CZE performance for the stable 99mTcO4- and 99mTc-DTPA compds. The data suggest that CZE may be used without problems for various Tc-compds. of intermediate mobilities. The specific data of 99mTc-citrate suggest that with this marker compd. a threshold lability is reached for the use of CZE in plant Tc-speciation studies. This result means that CZE cannot be used in analyses of Tc-compds. which are less stable than Tc-citrate. Future CZE work will comprise the synthesis and use of Tc-markers of intermediate mobilities and stabilities; furthermore, effects of marker matrixes and the plant matrix on CZE performance will be investigated. [on SciFinder (R)]
Original languageEnglish
Pages (from-to)29-36
JournalChemical Speciation and Bioavailability
Volume8
Issue number1/2
Publication statusPublished - 1996

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