TY - JOUR
T1 - On the relationship between dynamic contrast-enhanced ultrasound parameters and the underlying vascular architecture extracted from acoustic angiography
AU - Panfilova, Anastasiia
AU - Shelton, Sarah E.
AU - Caresio, Cristina
AU - van Sloun, Ruud J.G.
AU - Molinari, Filippo
AU - Wijkstra, Hessel
AU - Dayton, Paul A.
AU - Mischi, Massimo
PY - 2019/2
Y1 - 2019/2
N2 - Dynamic contrast-enhanced ultrasound (DCE-US) has been proposed as a powerful tool for cancer diagnosis by estimation of perfusion and dispersion parameters reflecting angiogenic vascular changes. This work was aimed at identifying which vascular features are reflected by the estimated perfusion and dispersion parameters through comparison with acoustic angiography (AA). AA is a high-resolution technique that allows quantification of vascular morphology. Three-dimensional AA and 2-D DCE-US bolus acquisitions were used to monitor the growth of fibrosarcoma tumors in nine rats. AA-derived vascular properties were analyzed along with DCE-US perfusion and dispersion to investigate the differences between tumor and control and their evolution in time. AA-derived microvascular density and DCE-US perfusion exhibited good agreement, confirmed by their spatial distributions. No vascular feature was correlated with dispersion. Yet, dispersion provided better cancer classification than perfusion. We therefore hypothesize that dispersion characterizes vessels that are smaller than those visible with AA.
AB - Dynamic contrast-enhanced ultrasound (DCE-US) has been proposed as a powerful tool for cancer diagnosis by estimation of perfusion and dispersion parameters reflecting angiogenic vascular changes. This work was aimed at identifying which vascular features are reflected by the estimated perfusion and dispersion parameters through comparison with acoustic angiography (AA). AA is a high-resolution technique that allows quantification of vascular morphology. Three-dimensional AA and 2-D DCE-US bolus acquisitions were used to monitor the growth of fibrosarcoma tumors in nine rats. AA-derived vascular properties were analyzed along with DCE-US perfusion and dispersion to investigate the differences between tumor and control and their evolution in time. AA-derived microvascular density and DCE-US perfusion exhibited good agreement, confirmed by their spatial distributions. No vascular feature was correlated with dispersion. Yet, dispersion provided better cancer classification than perfusion. We therefore hypothesize that dispersion characterizes vessels that are smaller than those visible with AA.
KW - Acoustic angiography
KW - Cancer
KW - Dispersion
KW - Dynamic contrast-enhanced ultrasound
KW - Perfusion
KW - Ultrasound contrast agents
KW - Angiography/methods
KW - Imaging, Three-Dimensional/methods
KW - Rats, Inbred F344
KW - Rats
KW - Ultrasonography/methods
KW - Acoustics
KW - Animals
KW - Contrast Media
KW - Image Enhancement/methods
KW - Fibrosarcoma/blood supply
KW - Disease Models, Animal
UR - http://www.scopus.com/inward/record.url?scp=85057487123&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2018.08.018
DO - 10.1016/j.ultrasmedbio.2018.08.018
M3 - Article
C2 - 30509785
VL - 45
SP - 539
EP - 548
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
SN - 0301-5629
IS - 2
ER -