On the physics underlying longitudinal capillary recruitment

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Numerous researchers have found that capillary vessel haematocrit depends on the vasodilatory state of the arterioles. At rest, vessel haematocrit is down to 15 %, suggesting a red blood cell velocity three times higher than the plasma velocity. This finding is analysed in the context of present understanding of propulsion of red blood cells (RBCs) and plasma by means of the arteriovenous pressure gradient. Interfacial forces between the red blood cells and the plasma are proposed as a rational explanation of the observed red blood cell velocities. While the arteriovenous pressure gradient across the capillaries propels the red blood cell and the plasma jointly, interfacial forces along the red blood cell membrane can propel RBCs at the cost of the plasma. Different options are explored for the physical origin of these interfacial forces and oxygen gradients are found to be the most probable source.

Original languageEnglish
Title of host publicationMolecular, cellular, and tissue engineering of the vascular system
EditorsBingmei M. Fu, Neil T. Wright
Place of PublicationBerlin
PublisherSpringer
Pages191-200
Number of pages10
ISBN (Electronic)978-3-319-96445-4
ISBN (Print)978-3-319-96444-7
DOIs
Publication statusPublished - 14 Oct 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1097
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Arterioles
  • Biomechanical Phenomena
  • Blood Flow Velocity
  • Blood Pressure
  • Capillaries/physiology
  • Cell Membrane
  • Erythrocytes
  • Hematocrit
  • Humans
  • Plasma

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  • Cite this

    Huyghe, J. M. (2018). On the physics underlying longitudinal capillary recruitment. In B. M. Fu, & N. T. Wright (Eds.), Molecular, cellular, and tissue engineering of the vascular system (pp. 191-200). (Advances in Experimental Medicine and Biology; Vol. 1097). Springer. https://doi.org/10.1007/978-3-319-96445-4_10