Offset-free model predictive control for enhancing MR-HIFU hyperthermia in cancer treatment⁎

D. A. Deenen; E. Maljaars; L. Sebeke; Bram de Jager; E. Heijman; H. Grüll; W. P.M.H. Heemels

doi:10.1016/j.ifacol.2018.11.012

Offset-free model predictive control for enhancing MR-HIFU hyperthermia in cancer treatment^⁎

D. A. Deenen, E. Maljaars, L. Sebeke, Bram de Jager, E. Heijman, H. Grüll, W. P.M.H. Heemels

Control Systems Technology

Research output: Contribution to journal › Conference article › peer-review

6 Citations (Scopus)

4 Downloads (Pure)

Abstract

In this paper, an offset-free MPC scheme is developed to improve performance and robustness of temperature control in magnetic resonance-guided high-intensity focused ultrasound hyperthermia cancer treatments. The proposed design effectively handles constraints and exploits the body's thermal behavior to achieve faster and more evenly distributed heating of the tumor leading to improved treatment quality with respect to the methods currently applied in clinics. The proposed scheme incorporates disturbance estimation to remove the steady-state offset resulting from plant-model mismatch, which for the given healthcare application is inevitable in practice due to the large physiological diversity in patients and tumors. Simulation results are presented to demonstrate this algorithm's capability to improve robust performance.

Original language	English
Pages (from-to)	191-196
Number of pages	6
Journal	IFAC-PapersOnLine
Volume	51
Issue number	20
DOIs	https://doi.org/10.1016/j.ifacol.2018.11.012
Publication status	Published - 22 Nov 2018
Event	6th IFAC Conference on Nonlinear Model Predictive Control NMPC 2018 - Madison, United States Duration: 19 Aug 2018 → 22 Aug 2018

Funding

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Keywords

cancer treatment
Healthcare
high-intensity focused ultrasound
hyperthermia
offset-free MPC

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ifacol.2018.11.012

Cite this

@article{998f2e6bbb8e4e17b77d52560ce8f406,

title = "Offset-free model predictive control for enhancing MR-HIFU hyperthermia in cancer treatment⁎",

abstract = "In this paper, an offset-free MPC scheme is developed to improve performance and robustness of temperature control in magnetic resonance-guided high-intensity focused ultrasound hyperthermia cancer treatments. The proposed design effectively handles constraints and exploits the body's thermal behavior to achieve faster and more evenly distributed heating of the tumor leading to improved treatment quality with respect to the methods currently applied in clinics. The proposed scheme incorporates disturbance estimation to remove the steady-state offset resulting from plant-model mismatch, which for the given healthcare application is inevitable in practice due to the large physiological diversity in patients and tumors. Simulation results are presented to demonstrate this algorithm's capability to improve robust performance.",

keywords = "cancer treatment, Healthcare, high-intensity focused ultrasound, hyperthermia, offset-free MPC",

author = "Deenen, {D. A.} and E. Maljaars and L. Sebeke and {de Jager}, Bram and E. Heijman and H. Gr{\"u}ll and Heemels, {W. P.M.H.}",

year = "2018",

month = nov,

day = "22",

doi = "10.1016/j.ifacol.2018.11.012",

language = "English",

volume = "51",

pages = "191--196",

journal = "IFAC-PapersOnLine",

issn = "2405-8963",

publisher = "Elsevier",

number = "20",

note = "6th IFAC Conference on Nonlinear Model Predictive Control NMPC 2018 ; Conference date: 19-08-2018 Through 22-08-2018",

}

TY - JOUR

T1 - Offset-free model predictive control for enhancing MR-HIFU hyperthermia in cancer treatment⁎

AU - Deenen, D. A.

AU - Maljaars, E.

AU - Sebeke, L.

AU - de Jager, Bram

AU - Heijman, E.

AU - Grüll, H.

AU - Heemels, W. P.M.H.

PY - 2018/11/22

Y1 - 2018/11/22

N2 - In this paper, an offset-free MPC scheme is developed to improve performance and robustness of temperature control in magnetic resonance-guided high-intensity focused ultrasound hyperthermia cancer treatments. The proposed design effectively handles constraints and exploits the body's thermal behavior to achieve faster and more evenly distributed heating of the tumor leading to improved treatment quality with respect to the methods currently applied in clinics. The proposed scheme incorporates disturbance estimation to remove the steady-state offset resulting from plant-model mismatch, which for the given healthcare application is inevitable in practice due to the large physiological diversity in patients and tumors. Simulation results are presented to demonstrate this algorithm's capability to improve robust performance.

AB - In this paper, an offset-free MPC scheme is developed to improve performance and robustness of temperature control in magnetic resonance-guided high-intensity focused ultrasound hyperthermia cancer treatments. The proposed design effectively handles constraints and exploits the body's thermal behavior to achieve faster and more evenly distributed heating of the tumor leading to improved treatment quality with respect to the methods currently applied in clinics. The proposed scheme incorporates disturbance estimation to remove the steady-state offset resulting from plant-model mismatch, which for the given healthcare application is inevitable in practice due to the large physiological diversity in patients and tumors. Simulation results are presented to demonstrate this algorithm's capability to improve robust performance.

KW - cancer treatment

KW - Healthcare

KW - high-intensity focused ultrasound

KW - hyperthermia

KW - offset-free MPC

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U2 - 10.1016/j.ifacol.2018.11.012

DO - 10.1016/j.ifacol.2018.11.012

M3 - Conference article

AN - SCOPUS:85056839860

SN - 2405-8963

VL - 51

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EP - 196

JO - IFAC-PapersOnLine

JF - IFAC-PapersOnLine

IS - 20

T2 - 6th IFAC Conference on Nonlinear Model Predictive Control NMPC 2018

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