Abstract
Motivation: The diagnosis of major depressive disorder (MDD) currently involves subjectivity, but an objective test based on a measurement is desired.
Goal(s): To obtain effective connections between brain networks from functional MRI that both allow MDD to be diagnosed and offer clinically relevant insight.
Approach: Stochastic Dynamic Causal Modelling is applied to the time series of resting-state networks. The most discriminative connections are found through Bayesian Model Reduction and Chi-Square feature selection. These connections are used for classification using machine learning.
Results: Eight clinically relevant effective connections result in 94% leave-one-out cross-validation accuracy, which resulted in 100% accuracy on a separate test set.
Impact: The discriminative ability of the eight resulting effective connections aid understanding of MDD's pathophysiology. Furthermore, the results may inspire researchers to investigate the eight most discriminative connections on other datasets, which can lead to an objective diagnostic biomarker for MDD.
Goal(s): To obtain effective connections between brain networks from functional MRI that both allow MDD to be diagnosed and offer clinically relevant insight.
Approach: Stochastic Dynamic Causal Modelling is applied to the time series of resting-state networks. The most discriminative connections are found through Bayesian Model Reduction and Chi-Square feature selection. These connections are used for classification using machine learning.
Results: Eight clinically relevant effective connections result in 94% leave-one-out cross-validation accuracy, which resulted in 100% accuracy on a separate test set.
Impact: The discriminative ability of the eight resulting effective connections aid understanding of MDD's pathophysiology. Furthermore, the results may inspire researchers to investigate the eight most discriminative connections on other datasets, which can lead to an objective diagnostic biomarker for MDD.
| Original language | English |
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| Publication status | Published - 20 Apr 2024 |
| Event | 2024 ISMRM & ISMRT Annual Meeting & Exhibition - Suntec Singapore Convention & Exhibition Centre, Singapore, Singapore Duration: 4 May 2024 → 9 May 2024 https://www.ismrm.org/24m/ |
Conference
| Conference | 2024 ISMRM & ISMRT Annual Meeting & Exhibition |
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| Country/Territory | Singapore |
| City | Singapore |
| Period | 4/05/24 → 9/05/24 |
| Internet address |