Numerical modelling of cell electrotaxis through single-dipole approximation

J.C. Vanegas Acosta, V. Lancellotti, A.P.M. Zwamborn

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


Electrotaxis is the cell migration induced by the presence of an external electric field (EF). It has been found that electrotaxis directs cell migration parallel to the EF and towards a preferential electrode. However, the internal cellular mechanisms affected by the external EF are not well understood. The goal of this work is to introduce a numerical framework for modelling electrotaxis by calculating the EF distribution inside the cells. The key assumption is that the cells (due to their dielectric nature) behave approximately as dipoles when exposed to an impressed EF. Besides, cell dynamics is described using two reaction-diffusion equations. Numerical results-obtained for osteogenic cell migration by electrotaxis - are in agreement with experimental reports and provide an insight into the cell-to-cell interactions in the presence of an external EF. Therefore, our model may constitute a methodological basis for the study of causal relations between EF and cells.
Original languageEnglish
Title of host publicationProceedings of the 42nd European Microwave Conference (EuMC), 30 October - 1 November 2012, Amsterdam, The Netherlands
Place of PublicationPiscataway
PublisherInstitute of Electrical and Electronics Engineers
ISBN (Print)978-2-87487-026-2
Publication statusPublished - 2012
Event42nd European Microwave Conference (EuMC 2012) - Amsterdam, Netherlands
Duration: 28 Oct 20122 Nov 2012
Conference number: 42


Conference42nd European Microwave Conference (EuMC 2012)
Abbreviated titleEuMC 2012
Other2012 42nd European Microwave Conference, EuMC 2012 - Held as Part of 15th European Microwave Week, EuMW 2012


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