Nuclear imaging approaches facilitating nanomedicine translation

Carlos Pérez-Medina (Corresponding author), Abraham J.P. Teunissen, Ewelina Kluza, Willem J.M. Mulder, Roy van der Meel (Corresponding author)

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Nanomedicine approaches can effectively modulate the biodistribution and bioavailability of therapeutic agents, improving their therapeutic index. However, despite the ever-increasing amount of literature reporting on preclinical nanomedicine, the number of nanotherapeutics receiving FDA approval remains relatively low. Several barriers exist that hamper the effective preclinical evaluation and clinical translation of nanotherapeutics. Key barriers include insufficient understanding of nanomedicines’ in vivo behavior, inadequate translation from murine models to larger animals, and a lack of patient stratification strategies. Integrating quantitative non-invasive imaging techniques in nanomedicine development offers attractive possibilities to address these issues. Among the available imaging techniques, nuclear imaging by positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are highly attractive in this context owing to their quantitative nature and uncontested sensitivity. In basic and translational research, nuclear imaging techniques can provide critical quantitative information about pharmacokinetic parameters, biodistribution profiles or target site accumulation of nanocarriers and their associated payload. During clinical evaluation, nuclear imaging can be used to select patients amenable to nanomedicine treatment. Here, we review how nuclear imaging-based approaches are increasingly being integrated into nanomedicine development and discuss future developments that will accelerate their clinical translation.
Original languageEnglish
JournalAdvanced Drug Delivery Reviews
DOIs
Publication statusE-pub ahead of print - 25 Jul 2020

Keywords

  • Clinical translation
  • Nanomedicine
  • Positron emission tomography
  • Quantitative imaging
  • Radiolabeling
  • Single-photon emission computed tomography

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