Novel therapies for epilepsy in the pipeline

Boulenouar Mesraoua (Corresponding author), Dirk Deleu, Dimitri M. Kullmann, Ashok K. Shetty, Paul Boon, Emilio Perucca, Mohamad A. Mikati, A. A. Asadi-Pooya

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)


Despite the availability of many antiepileptic drugs (AEDs) (old and newly developed) and, as recently suggested, their optimization in the treatment of patients with uncontrolled seizures, more than 30% of patients with epilepsy continue to experience seizures and have drug-resistant epilepsy; the management of these patients represents a real challenge for epileptologists and researchers. Resective surgery with the best rates of seizure control is not an option for all of them; therefore, research and discovery of new methods of treating resistant epilepsy are of extreme importance. In this article, we will discuss some innovative approaches, such as P-glycoprotein (P-gp) inhibitors, gene therapy, stem cell therapy, traditional and novel antiepileptic devices, precision medicine, as well as therapeutic advances in epileptic encephalopathy in children; these treatment modalities open up new horizons for the treatment of patients with drug-resistant epilepsy.

Original languageEnglish
Pages (from-to)282-290
Number of pages9
JournalEpilepsy and Behavior
Publication statusPublished - Aug 2019


  • Drug resistance
  • Epilepsy
  • Seizure
  • Treatment


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