Novel lipidomimetic compounds and uses thereof

Holger Gruell; Sander Langereis; Johan Lub

Novel lipidomimetic compounds and uses thereof

Holger Gruell (Inventor), Sander Langereis (Inventor), Johan Lub (Inventor)

Research output: Patent › Patent publication

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Abstract

Disclosed are lipidomimetic compounds of formula I (I) wherein: G represents a group satisfying formula II: HO-CH2-{CH(OH)-CH2-0}m-CH2-{C(=0)-0-CH2}q- formula II each n independently is an integer from 1-30; m is an integer from 1-10; q is 0 or 1. These compounds can be added to the lipid bilayer of thermosensitive liposomes, for the purpose of aiding in the prevention of leakage of the liposomes' contents at 37°C, and retarding clearance from circulation.

Original language	English
Patent number	WO2012172457
IPC	C07C 69/ 708 A I
Priority date	16/06/11
Publication status	Published - 20 Dec 2012

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title = "Novel lipidomimetic compounds and uses thereof",

abstract = "Disclosed are lipidomimetic compounds of formula I (I) wherein: G represents a group satisfying formula II: HO-CH2-{CH(OH)-CH2-0}m-CH2-{C(=0)-0-CH2}q- formula II each n independently is an integer from 1-30; m is an integer from 1-10; q is 0 or 1. These compounds can be added to the lipid bilayer of thermosensitive liposomes, for the purpose of aiding in the prevention of leakage of the liposomes' contents at 37°C, and retarding clearance from circulation.",

author = "Holger Gruell and Sander Langereis and Johan Lub",

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T1 - Novel lipidomimetic compounds and uses thereof

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AU - Langereis, Sander

AU - Lub, Johan

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N2 - Disclosed are lipidomimetic compounds of formula I (I) wherein: G represents a group satisfying formula II: HO-CH2-{CH(OH)-CH2-0}m-CH2-{C(=0)-0-CH2}q- formula II each n independently is an integer from 1-30; m is an integer from 1-10; q is 0 or 1. These compounds can be added to the lipid bilayer of thermosensitive liposomes, for the purpose of aiding in the prevention of leakage of the liposomes' contents at 37°C, and retarding clearance from circulation.

AB - Disclosed are lipidomimetic compounds of formula I (I) wherein: G represents a group satisfying formula II: HO-CH2-{CH(OH)-CH2-0}m-CH2-{C(=0)-0-CH2}q- formula II each n independently is an integer from 1-30; m is an integer from 1-10; q is 0 or 1. These compounds can be added to the lipid bilayer of thermosensitive liposomes, for the purpose of aiding in the prevention of leakage of the liposomes' contents at 37°C, and retarding clearance from circulation.

M3 - Patent publication

M1 - WO2012172457

ER -

Novel lipidomimetic compounds and uses thereof

Abstract

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