Novel lipidomimetic compounds and uses thereof

Holger Gruell (Inventor), Sander Langereis (Inventor), Johan Lub (Inventor)

    Research output: PatentPatent publication

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    Disclosed are lipidomimetic compounds of formula I (I) wherein: G represents a group satisfying formula II: HO-CH2-{CH(OH)-CH2-0}m-CH2-{C(=0)-0-CH2})q- formula II each n independently is an integer from 1-30; m is an integer from 1-10; q is 0 or 1. These compounds can be added to the lipid bilayer of thermosensitive liposomes, for the purpose of aiding in the prevention of leakage of the liposomes' contents at 37 DEG C., and retarding clearance from circulation.

    Original languageEnglish
    Patent numberUS2014127135
    IPCA61K 49/ 18 A I
    Priority date6/06/12
    Publication statusPublished - 8 May 2014


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