Novel forsterite/polycaprolactone nanocomposite scaffold for tissue engineering applications

Mani Diba (Corresponding author), M. H. Fathi, M. Kharaziha

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)

Abstract

Novel highly porous nanocomposite scaffolds consisting of polycaprolactone (PCL) and forsterite nanopowder were prepared by a solvent-casting/particle- leaching method. In addition, the effects of forsterite nanopowder contents on the structure of the scaffolds were investigated to provide an appropriate composite for bone regenerative medicine. Results showed that the scaffolds exhibited high porosity (up to 92%) with open pores of 100-300 μm average diameters. This porosity increased with decreasing forsterite nanopowder content. In addition, the pore walls contained numerous micropores. Microstructure studies showed that the pores were well distributed throughout the structures. Furthermore, the bioactive forsterite nanoparticles were homogenously distributed within the PCL matrix of the scaffolds, which contained up to 30 wt.% forsterite nanopowder. This porous structure with micropores provides the properties required for bone tissue engineering applications.

Original languageEnglish
Pages (from-to)1931-1934
Number of pages4
JournalMaterials Letters
Volume65
Issue number12
DOIs
Publication statusPublished - 30 Jun 2011
Externally publishedYes

Keywords

  • Forsterite nanopowder
  • Nanocomposites
  • Porosity
  • Scaffold

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