Novel biodegradable heterografted polymer brushes prepared via a chemoenzymatic approach

M. Hans, Y. Xiao, H. Keul, A. Heise, M. Möller

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Abstract

Biodegradable heterografted molecular bottle brushes were prepared in two steps starting with a linear polyglycidol as a macroinitiator. First, ca. 45% of the polyglycidol hydroxy groups were grafted with e-caprolactone via enzymatic catalysis. Selective end capping of the hydroxy groups at the graft ends was achieved via enzymatic esterification with vinyl acetate or vinyl acrylate. Finally, poly(L-lactide) grafts were attached to the remaining polyglycidol hydroxy groups by chemically catalyzed ring-opening polymerization. The successful synthesis of the heterografted comb-shaped brushes was confirmed by NMR and SEC analyses. Additionally, the feasibility of microsphere formulation was described. © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)736-746
JournalMacromolecular Chemistry and Physics
Volume210
Issue number9
DOIs
Publication statusPublished - 2009

Fingerprint

Biodegradable polymers
brushes
Brushes
Grafts
Ring opening polymerization
Esterification
polymers
Bottles
Microspheres
Catalysis
bottles
Nuclear magnetic resonance
acrylates
catalysis
acetates
polymerization
formulations
nuclear magnetic resonance
rings
synthesis

Cite this

Hans, M. ; Xiao, Y. ; Keul, H. ; Heise, A. ; Möller, M. / Novel biodegradable heterografted polymer brushes prepared via a chemoenzymatic approach. In: Macromolecular Chemistry and Physics. 2009 ; Vol. 210, No. 9. pp. 736-746.
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Novel biodegradable heterografted polymer brushes prepared via a chemoenzymatic approach. / Hans, M.; Xiao, Y.; Keul, H.; Heise, A.; Möller, M.

In: Macromolecular Chemistry and Physics, Vol. 210, No. 9, 2009, p. 736-746.

Research output: Contribution to journalArticleAcademicpeer-review

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AB - Biodegradable heterografted molecular bottle brushes were prepared in two steps starting with a linear polyglycidol as a macroinitiator. First, ca. 45% of the polyglycidol hydroxy groups were grafted with e-caprolactone via enzymatic catalysis. Selective end capping of the hydroxy groups at the graft ends was achieved via enzymatic esterification with vinyl acetate or vinyl acrylate. Finally, poly(L-lactide) grafts were attached to the remaining polyglycidol hydroxy groups by chemically catalyzed ring-opening polymerization. The successful synthesis of the heterografted comb-shaped brushes was confirmed by NMR and SEC analyses. Additionally, the feasibility of microsphere formulation was described. © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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