Abstract
Biodegradable heterografted molecular bottle brushes were prepared in two steps starting with a linear polyglycidol as a macroinitiator. First, ca. 45% of the polyglycidol hydroxy groups were grafted with e-caprolactone via enzymatic catalysis. Selective end capping of the hydroxy groups at the graft ends was achieved via enzymatic esterification with vinyl acetate or vinyl acrylate. Finally, poly(L-lactide) grafts were attached to the remaining polyglycidol hydroxy groups by chemically catalyzed ring-opening polymerization. The successful synthesis of the heterografted comb-shaped brushes was confirmed by NMR and SEC analyses. Additionally, the feasibility of microsphere formulation was described. © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original language | English |
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Pages (from-to) | 736-746 |
Journal | Macromolecular Chemistry and Physics |
Volume | 210 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2009 |