Non-invasive assessment of leaflet deformation in heart valve tissue engineering

J. Kortsmit, N.M. Driessen, M.C.M. Rutten, F.P.T. Baaijens

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


Contemporary tissue engineered heart valves seem to have sufficient mechanical strength for implantation [1]. Nevertheless, mechanical properties, tissue structure and architecture still need to be improved. Recent studies indicate enhancement of mechanical properties by applying cyclic diastolic pressure loads to the developing tissue in a bioreactor system [2]. However, current bioreactors operate with a preset transvalvular pressure applied to the tissue. Mechanical properties of the engineered construct may vary during culturing and consequently, the pressure-induced deformations are unknown. To systematically study the effects of mechanical straining on tissue development and to design an optimal conditioning protocol, real-time measurement and control of local tissue strains are desired.
Original languageEnglish
Title of host publicationProceedings of the ASME 2007 Summer Bioengineering Conference (SBC 2007) 20-24 June 2007, Keystone, Colorado, USA
Place of PublicationKeystone, Colorado, USA
Publication statusPublished - 2007
EventASME 2007 Summer Bioengineering Conference (SBC 2007) - Keystone, United States
Duration: 20 Jun 200724 Jun 2007


ConferenceASME 2007 Summer Bioengineering Conference (SBC 2007)
Abbreviated titleSBC 2007
Country/TerritoryUnited States


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