Non-covalent microgel particles containing functional payloads: coacervation of PEG-based triblocks via microfluidics

Cynthia X. Wang, Stefanie Utech, Jeffrey D. Gopez, Mathijs F.J. Mabesoone, Craig J. Hawker, Daniel Klinger

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

Well-defined microgel particles were prepared by combining coacervate-driven cross-linking of ionic triblock copolymers with the ability to control particle size and encapsulate functional cargos inherent in microfluidic devices. In this approach, the efficient assembly of PEO-based triblock copolymers with oppositely charged end-blocks allows for bioinspired cross-linking under mild conditions in dispersed aqueous droplets. This strategy enables the integration of charged cargos into the coacervate domains (e.g., the loading of anionic model compounds through electrostatic association with cationic end-blocks). Distinct release profiles can be realized by systematically varying the chemical nature of the payload and the microgel dimensions. This mild and noncovalent assembly method represents a promising new approach to tunable microgels as scaffolds for colloidal biomaterials in therapeutics and regenerative medicine
LanguageEnglish
Pages16914-16921
Number of pages8
JournalACS Applied Materials & Interfaces
Volume8
Issue number26
DOIs
StatePublished - 6 Jul 2016

Keywords

  • microgels
  • droplet microfluidics
  • triblock copolymers
  • polyelectrolytes
  • coacervates
  • physical cross-links

Cite this

Wang, Cynthia X. ; Utech, Stefanie ; Gopez, Jeffrey D. ; Mabesoone, Mathijs F.J. ; Hawker, Craig J. ; Klinger, Daniel. / Non-covalent microgel particles containing functional payloads: coacervation of PEG-based triblocks via microfluidics. In: ACS Applied Materials & Interfaces. 2016 ; Vol. 8, No. 26. pp. 16914-16921
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abstract = "Well-defined microgel particles were prepared by combining coacervate-driven cross-linking of ionic triblock copolymers with the ability to control particle size and encapsulate functional cargos inherent in microfluidic devices. In this approach, the efficient assembly of PEO-based triblock copolymers with oppositely charged end-blocks allows for bioinspired cross-linking under mild conditions in dispersed aqueous droplets. This strategy enables the integration of charged cargos into the coacervate domains (e.g., the loading of anionic model compounds through electrostatic association with cationic end-blocks). Distinct release profiles can be realized by systematically varying the chemical nature of the payload and the microgel dimensions. This mild and noncovalent assembly method represents a promising new approach to tunable microgels as scaffolds for colloidal biomaterials in therapeutics and regenerative medicine",
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Non-covalent microgel particles containing functional payloads: coacervation of PEG-based triblocks via microfluidics. / Wang, Cynthia X.; Utech, Stefanie; Gopez, Jeffrey D.; Mabesoone, Mathijs F.J.; Hawker, Craig J.; Klinger, Daniel.

In: ACS Applied Materials & Interfaces, Vol. 8, No. 26, 06.07.2016, p. 16914-16921.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Non-covalent microgel particles containing functional payloads: coacervation of PEG-based triblocks via microfluidics

AU - Wang,Cynthia X.

AU - Utech,Stefanie

AU - Gopez,Jeffrey D.

AU - Mabesoone,Mathijs F.J.

AU - Hawker,Craig J.

AU - Klinger,Daniel

PY - 2016/7/6

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AB - Well-defined microgel particles were prepared by combining coacervate-driven cross-linking of ionic triblock copolymers with the ability to control particle size and encapsulate functional cargos inherent in microfluidic devices. In this approach, the efficient assembly of PEO-based triblock copolymers with oppositely charged end-blocks allows for bioinspired cross-linking under mild conditions in dispersed aqueous droplets. This strategy enables the integration of charged cargos into the coacervate domains (e.g., the loading of anionic model compounds through electrostatic association with cationic end-blocks). Distinct release profiles can be realized by systematically varying the chemical nature of the payload and the microgel dimensions. This mild and noncovalent assembly method represents a promising new approach to tunable microgels as scaffolds for colloidal biomaterials in therapeutics and regenerative medicine

KW - microgels

KW - droplet microfluidics

KW - triblock copolymers

KW - polyelectrolytes

KW - coacervates

KW - physical cross-links

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