Nachtelijke stridor bij multipele systeematrofie

Translated title of the contribution: Nocturnal stridor in multiple system atrophy

M. Louter, R.H. Pelleboer, G.B. van den Broek, B. Post, D.A.A. Pevernagie, S. Overeem

Research output: Contribution to journalArticleAcademicpeer-review

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BACKGROUND: Multiple system atrophy is a neurodegenerative disorder with parkinsonism, cerebellar ataxia and autonomic dysfunction. The occurrence of nocturnal stridor in patients with multiple system atrophy is associated with a decreased life expectancy. This is what makes adequate treatment so important. Nevertheless, stridor goes often unrecognized and there is frequent uncertainty about the therapeutic options.

CASE: We present a 58-year-old woman with multiple system atrophy and nocturnal stridor. Direct laryngoscopy showed bilateral paresis of the vocal cords and glottic stenosis. Since the outcome of treatment with continuous positive airway pressure (CPAP) was unsatisfactory, a tracheotomy was performed after which the stridor disappeared.

CONCLUSION: Polysomnography and laryngoscopy are the important diagnostic tools for this condition, after the clinical interview. Tracheotomy used to be the only therapeutic option for stridor. However, recent studies show a comparable effectiveness of non-invasive treatment with CPAP, provided there is a correct indication. The choice of therapy is a multidisciplinary process in which the neurologist, the sleep medicine specialist, the otolaryngologist, and the patient are involved.

Translated title of the contributionNocturnal stridor in multiple system atrophy
Original languageDutch
Pages (from-to)A3621
Number of pages5
JournalNederlands Tijdschrift voor Geneeskunde
Issue number46
Publication statusPublished - 2011
Externally publishedYes


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  • English Abstract
  • Journal Article

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