No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood

Dutch POPS-19 Collaborative Study Group, Peter Andriessen

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)


Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood. Objective:Theobjectivewastoexaminewhetherthere isaneffect ofTHoPonintelligence quotient (IQ) score and motor functioning at a young adult age. Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,<32 wk) and/or with a very low birth weight (ie, <1500 g). Setting: This was a multicenter study. Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP. Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoPwasdefined as a total T4 concentration <-3 SDof the dailymean (approximately 60 nmol/L). Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen's examination of minor neurological dysfunction, respectively. Results: THoP was not associated with IQ score (mean difference, 0 [95% confidence interval,-3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, -1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics. Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found.

Original languageEnglish
Pages (from-to)4648-4653
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Issue number12
Publication statusPublished - 1 Dec 2015
Externally publishedYes


  • Cohort Studies
  • Congenital Hypothyroidism/complications
  • Developmental Disabilities/epidemiology
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Extremely Premature
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Infant, Premature
  • Infant, Small for Gestational Age
  • Intelligence Tests
  • Male
  • Nervous System Diseases/epidemiology
  • Neuropsychological Tests
  • Psychomotor Performance
  • Thyroxine/blood
  • Young Adult


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