No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood

Dutch POPS-19 Collaborative Study Group, Peter Andriessen

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Abstract

Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood. Objective:Theobjectivewastoexaminewhetherthere isaneffect ofTHoPonintelligence quotient (IQ) score and motor functioning at a young adult age. Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,<32 wk) and/or with a very low birth weight (ie, <1500 g). Setting: This was a multicenter study. Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP. Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoPwasdefined as a total T4 concentration <-3 SDof the dailymean (approximately 60 nmol/L). Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen's examination of minor neurological dysfunction, respectively. Results: THoP was not associated with IQ score (mean difference, 0 [95% confidence interval,-3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, -1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics. Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found.

Original languageEnglish
Pages (from-to)4648-4653
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number12
DOIs
Publication statusPublished - 1 Dec 2015
Externally publishedYes

Fingerprint

Outcome Assessment (Health Care)
Confidence Intervals
Neonatal Screening
Congenital Hypothyroidism
Very Low Birth Weight Infant
Neurologic Examination
Multicenter Studies
Young Adult
Demography
Parturition
Screening

Keywords

  • Cohort Studies
  • Congenital Hypothyroidism/complications
  • Developmental Disabilities/epidemiology
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Extremely Premature
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Infant, Premature
  • Infant, Small for Gestational Age
  • Intelligence Tests
  • Male
  • Nervous System Diseases/epidemiology
  • Neuropsychological Tests
  • Psychomotor Performance
  • Thyroxine/blood
  • Young Adult

Cite this

@article{4e0ac923bfa24254934efc4dea0e41b8,
title = "No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood",
abstract = "Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood. Objective:Theobjectivewastoexaminewhetherthere isaneffect ofTHoPonintelligence quotient (IQ) score and motor functioning at a young adult age. Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,<32 wk) and/or with a very low birth weight (ie, <1500 g). Setting: This was a multicenter study. Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP. Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoPwasdefined as a total T4 concentration <-3 SDof the dailymean (approximately 60 nmol/L). Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen's examination of minor neurological dysfunction, respectively. Results: THoP was not associated with IQ score (mean difference, 0 [95{\%} confidence interval,-3.8 to 3.8] points) or motor function (mean difference, 0.6 [95{\%} confidence interval, -1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics. Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found.",
keywords = "Cohort Studies, Congenital Hypothyroidism/complications, Developmental Disabilities/epidemiology, Female, Follow-Up Studies, Humans, Infant, Extremely Premature, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Small for Gestational Age, Intelligence Tests, Male, Nervous System Diseases/epidemiology, Neuropsychological Tests, Psychomotor Performance, Thyroxine/blood, Young Adult",
author = "{Dutch POPS-19 Collaborative Study Group} and Hollanders, {Jonneke J.} and Jo{\"e}l Isra{\"e}ls and {van der Pal}, {Sylvia M.} and Verkerk, {Paul H.} and Joost Rotteveel and Finken, {Martijn J.J.} and Hille, {E. T.M.} and {de Groot}, {C. H.} and H. Kloosterboer-Boerrigter and {den Ouden}, {A. L.} and A. Rijpstra and Verloove-Vanhorick, {S. P.} and Vogelaar, {J. A.} and Kok, {J. H.} and A. Ilsen and {van der Lans}, M. and {Boelen-van der Loo}, {W. J.C.} and T. Lundqvist and Heymans, {H. S.A.} and Duiverman, {E. J.} and Geven, {W. B.} and Duiverman, {M. L.} and Geven, {L. I.} and Vrijlandt, {E. J.L.E.} and Mulder, {A. L.M.} and A. Gerver and Koll{\'e}e, {L. A.A.} and L. Reijmers and R. Sonnemans and Wit, {J. M.} and Dekker, {F. W.} and Finken, {M. J.J.} and N. Weisglas-Kuperus and Keijzer-Veen, {M. G.} and {van der Heijden}, {A. J.} and {van Goudoever}, {J. B.} and {van Weissenbruch}, {M. M.} and A. Cranendonk and {Delemarre-van de Waal}, {H. A.} and {de Groot}, L. and Samsom, {J. F.} and {de Vries}, {Linda S.} and Rademaker, {K. J.} and E. Moerman and M. Voogsgeerd and {de Kleine}, {M. J.K.} and Peter Andriessen and {Dielissen-van Helvoirt}, C.C.M. and I. Mohamed and {van Straaten}, {H. L.M.}",
year = "2015",
month = "12",
day = "1",
doi = "10.1210/jc.2015-3078",
language = "English",
volume = "100",
pages = "4648--4653",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "12",

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No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood. / Dutch POPS-19 Collaborative Study Group ; Andriessen, Peter.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 12, 01.12.2015, p. 4648-4653.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood

AU - Dutch POPS-19 Collaborative Study Group

AU - Hollanders, Jonneke J.

AU - Israëls, Joël

AU - van der Pal, Sylvia M.

AU - Verkerk, Paul H.

AU - Rotteveel, Joost

AU - Finken, Martijn J.J.

AU - Hille, E. T.M.

AU - de Groot, C. H.

AU - Kloosterboer-Boerrigter, H.

AU - den Ouden, A. L.

AU - Rijpstra, A.

AU - Verloove-Vanhorick, S. P.

AU - Vogelaar, J. A.

AU - Kok, J. H.

AU - Ilsen, A.

AU - van der Lans, M.

AU - Boelen-van der Loo, W. J.C.

AU - Lundqvist, T.

AU - Heymans, H. S.A.

AU - Duiverman, E. J.

AU - Geven, W. B.

AU - Duiverman, M. L.

AU - Geven, L. I.

AU - Vrijlandt, E. J.L.E.

AU - Mulder, A. L.M.

AU - Gerver, A.

AU - Kollée, L. A.A.

AU - Reijmers, L.

AU - Sonnemans, R.

AU - Wit, J. M.

AU - Dekker, F. W.

AU - Finken, M. J.J.

AU - Weisglas-Kuperus, N.

AU - Keijzer-Veen, M. G.

AU - van der Heijden, A. J.

AU - van Goudoever, J. B.

AU - van Weissenbruch, M. M.

AU - Cranendonk, A.

AU - Delemarre-van de Waal, H. A.

AU - de Groot, L.

AU - Samsom, J. F.

AU - de Vries, Linda S.

AU - Rademaker, K. J.

AU - Moerman, E.

AU - Voogsgeerd, M.

AU - de Kleine, M. J.K.

AU - Andriessen, Peter

AU - Dielissen-van Helvoirt, C.C.M.

AU - Mohamed, I.

AU - van Straaten, H. L.M.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood. Objective:Theobjectivewastoexaminewhetherthere isaneffect ofTHoPonintelligence quotient (IQ) score and motor functioning at a young adult age. Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,<32 wk) and/or with a very low birth weight (ie, <1500 g). Setting: This was a multicenter study. Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP. Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoPwasdefined as a total T4 concentration <-3 SDof the dailymean (approximately 60 nmol/L). Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen's examination of minor neurological dysfunction, respectively. Results: THoP was not associated with IQ score (mean difference, 0 [95% confidence interval,-3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, -1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics. Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found.

AB - Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood. Objective:Theobjectivewastoexaminewhetherthere isaneffect ofTHoPonintelligence quotient (IQ) score and motor functioning at a young adult age. Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,<32 wk) and/or with a very low birth weight (ie, <1500 g). Setting: This was a multicenter study. Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP. Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoPwasdefined as a total T4 concentration <-3 SDof the dailymean (approximately 60 nmol/L). Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen's examination of minor neurological dysfunction, respectively. Results: THoP was not associated with IQ score (mean difference, 0 [95% confidence interval,-3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, -1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics. Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found.

KW - Cohort Studies

KW - Congenital Hypothyroidism/complications

KW - Developmental Disabilities/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Infant, Extremely Premature

KW - Infant, Low Birth Weight

KW - Infant, Newborn

KW - Infant, Premature

KW - Infant, Small for Gestational Age

KW - Intelligence Tests

KW - Male

KW - Nervous System Diseases/epidemiology

KW - Neuropsychological Tests

KW - Psychomotor Performance

KW - Thyroxine/blood

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=84951183148&partnerID=8YFLogxK

U2 - 10.1210/jc.2015-3078

DO - 10.1210/jc.2015-3078

M3 - Article

C2 - 26480285

VL - 100

SP - 4648

EP - 4653

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 12

ER -