TY - JOUR
T1 - No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood
AU - Dutch POPS-19 Collaborative Study Group
AU - Hollanders, Jonneke J.
AU - Israëls, Joël
AU - van der Pal, Sylvia M.
AU - Verkerk, Paul H.
AU - Rotteveel, Joost
AU - Finken, Martijn J.J.
AU - Hille, E. T.M.
AU - de Groot, C. H.
AU - Kloosterboer-Boerrigter, H.
AU - den Ouden, A. L.
AU - Rijpstra, A.
AU - Verloove-Vanhorick, S. P.
AU - Vogelaar, J. A.
AU - Kok, J. H.
AU - Ilsen, A.
AU - van der Lans, M.
AU - Boelen-van der Loo, W. J.C.
AU - Lundqvist, T.
AU - Heymans, H. S.A.
AU - Duiverman, E. J.
AU - Geven, W. B.
AU - Duiverman, M. L.
AU - Geven, L. I.
AU - Vrijlandt, E. J.L.E.
AU - Mulder, A. L.M.
AU - Gerver, A.
AU - Kollée, L. A.A.
AU - Reijmers, L.
AU - Sonnemans, R.
AU - Wit, J. M.
AU - Dekker, F. W.
AU - Finken, M. J.J.
AU - Weisglas-Kuperus, N.
AU - Keijzer-Veen, M. G.
AU - van der Heijden, A. J.
AU - van Goudoever, J. B.
AU - van Weissenbruch, M. M.
AU - Cranendonk, A.
AU - Delemarre-van de Waal, H. A.
AU - de Groot, L.
AU - Samsom, J. F.
AU - de Vries, Linda S.
AU - Rademaker, K. J.
AU - Moerman, E.
AU - Voogsgeerd, M.
AU - de Kleine, M. J.K.
AU - Andriessen, Peter
AU - Dielissen-van Helvoirt, C.C.M.
AU - Mohamed, I.
AU - van Straaten, H. L.M.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood. Objective:Theobjectivewastoexaminewhetherthere isaneffect ofTHoPonintelligence quotient (IQ) score and motor functioning at a young adult age. Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,<32 wk) and/or with a very low birth weight (ie, <1500 g). Setting: This was a multicenter study. Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP. Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoPwasdefined as a total T4 concentration <-3 SDof the dailymean (approximately 60 nmol/L). Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen's examination of minor neurological dysfunction, respectively. Results: THoP was not associated with IQ score (mean difference, 0 [95% confidence interval,-3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, -1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics. Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found.
AB - Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood. Objective:Theobjectivewastoexaminewhetherthere isaneffect ofTHoPonintelligence quotient (IQ) score and motor functioning at a young adult age. Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,<32 wk) and/or with a very low birth weight (ie, <1500 g). Setting: This was a multicenter study. Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP. Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoPwasdefined as a total T4 concentration <-3 SDof the dailymean (approximately 60 nmol/L). Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen's examination of minor neurological dysfunction, respectively. Results: THoP was not associated with IQ score (mean difference, 0 [95% confidence interval,-3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, -1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics. Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found.
KW - Cohort Studies
KW - Congenital Hypothyroidism/complications
KW - Developmental Disabilities/epidemiology
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Infant, Extremely Premature
KW - Infant, Low Birth Weight
KW - Infant, Newborn
KW - Infant, Premature
KW - Infant, Small for Gestational Age
KW - Intelligence Tests
KW - Male
KW - Nervous System Diseases/epidemiology
KW - Neuropsychological Tests
KW - Psychomotor Performance
KW - Thyroxine/blood
KW - Young Adult
UR - http://www.scopus.com/inward/record.url?scp=84951183148&partnerID=8YFLogxK
U2 - 10.1210/jc.2015-3078
DO - 10.1210/jc.2015-3078
M3 - Article
C2 - 26480285
VL - 100
SP - 4648
EP - 4653
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 12
ER -