NMR characterization of a Cu(I)-bound peptide model of copper metallochaperones: Insights on the role of methionine

M.S. Shosham, D.E. Shalev, W. Adriaens, M. Merkx, T.M. Hackeng, E.Y. Tshuva

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

The first NMR structure of a Cu(I)-bound metallochaperone model with the conserved sequence MT/HCXXC revealed that at pH 3.0 and 6.8 Cu(I) binds through one Cys and the Met rather than the two Cys residues, differently than at pH 8.5. This suggests a possible role of Met in metal transport.
Original languageEnglish
Pages (from-to)6407-6409
Number of pages3
JournalChemical Communications
Volume47
Issue number22
DOIs
Publication statusPublished - 2011

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