New compound classes: Protein–protein interactions

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Protein-protein interactions (PPIs) are one of the most promising new targets in drug discovery. With estimates between 300,000 and 650,000 in human physiology, targeted modulation of PPIs would tremendously extend the "druggable" genome. In fact, in every disease a wealth of potentially addressable PPIs can be found making pharmacological intervention based on PPI modulators in principle a generally applicable technology. An impressing number of success stories in small-molecule PPI inhibition and natural-product PPI stabilization increasingly encourage academia and industry to invest in PPI modulation. In this chapter examples of both inhibition as well as stabilization of PPIs are reviewed including some of the technologies which has been used for their identification
Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
EditorsU. Nielsch, U. Fuhrmann, S. Jaroch
Place of PublicationBerlin
Number of pages14
ISBN (Electronic)978-3-319-28914-4
ISBN (Print)978-3-319-28912-0
Publication statusPublished - 1 Apr 2016

Publication series

NameHandbook of experimental pharmacology
ISSN (Print)0171-2004


  • Natural products
  • PPI inhibition
  • PPI stabilization
  • Small-molecules
  • X-ray crystallography


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