Neurodevelopmental outcome in full-term newborns with refractory neonatal seizures

Imke A Maartens, Tessa Wassenberg, Jan Buijs, Levinus Bok, Martin J.K. de Kleine, Titia Katgert, Peter Andriessen

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

AIM: This retrospective study describes the prognosis of full-term newborns with refractory neonatal seizures, comparing the need for treatment with two versus three or more antiepileptic drugs.

METHODS: We reviewed our database (January 2002-December 2007) to include newborns with refractory neonatal seizures and abnormal electroencephalogram. Group A consisted of 17 newborns with two antiepileptic drugs. Group B consisted of 29 newborns with three or more antiepileptic drugs. Outcome was determined at 2 years of age using the Dutch Bayley Scales of Infant Development or a neurodevelopmental classification scheme.

RESULTS: Group A and group B were comparable regarding to a variety of demographic and aetiologic factors. Thirteen newborns died before 2 years of age and one was lost to follow-up. Normal development at 2 years of age was found in 50% and 5% for group A and B, respectively. Severe neurodevelopmental delay at 2 years of age was found in 30% and 68% for group A and B, respectively.

CONCLUSION: The number of antiepileptic drugs probably reflects increased seizure burden and is--in that way--related to poor outcome. This may be useful information for early prediction of adverse neurological outcome in the first days of life.

Original languageEnglish
Pages (from-to)e173-e178
JournalActa Paediatrica
Volume101
Issue number4
DOIs
Publication statusPublished - Apr 2012
Externally publishedYes

Keywords

  • Anticonvulsants/therapeutic use
  • Child Development/drug effects
  • Child, Preschool
  • Developmental Disabilities/epidemiology
  • Drug Therapy, Combination
  • Epilepsy, Benign Neonatal/drug therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Male
  • Nervous System/growth & development
  • Prognosis
  • Retrospective Studies
  • Seizures/drug therapy
  • Term Birth
  • Treatment Outcome

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