Neurodevelopmental outcome in full-term newborns with refractory neonatal seizures

Imke A Maartens, Tessa Wassenberg, Jan Buijs, Levinus Bok, Martin J.K. de Kleine, Titia Katgert, Peter Andriessen

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

AIM: This retrospective study describes the prognosis of full-term newborns with refractory neonatal seizures, comparing the need for treatment with two versus three or more antiepileptic drugs.

METHODS: We reviewed our database (January 2002-December 2007) to include newborns with refractory neonatal seizures and abnormal electroencephalogram. Group A consisted of 17 newborns with two antiepileptic drugs. Group B consisted of 29 newborns with three or more antiepileptic drugs. Outcome was determined at 2 years of age using the Dutch Bayley Scales of Infant Development or a neurodevelopmental classification scheme.

RESULTS: Group A and group B were comparable regarding to a variety of demographic and aetiologic factors. Thirteen newborns died before 2 years of age and one was lost to follow-up. Normal development at 2 years of age was found in 50% and 5% for group A and B, respectively. Severe neurodevelopmental delay at 2 years of age was found in 30% and 68% for group A and B, respectively.

CONCLUSION: The number of antiepileptic drugs probably reflects increased seizure burden and is--in that way--related to poor outcome. This may be useful information for early prediction of adverse neurological outcome in the first days of life.

Original languageEnglish
Pages (from-to)e173-e178
JournalActa Paediatrica
Volume101
Issue number4
DOIs
Publication statusPublished - Apr 2012
Externally publishedYes

Fingerprint

Anticonvulsants
Seizures
Lost to Follow-Up
Child Development
Electroencephalography
Retrospective Studies
Demography
Databases

Keywords

  • Anticonvulsants/therapeutic use
  • Child Development/drug effects
  • Child, Preschool
  • Developmental Disabilities/epidemiology
  • Drug Therapy, Combination
  • Epilepsy, Benign Neonatal/drug therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Male
  • Nervous System/growth & development
  • Prognosis
  • Retrospective Studies
  • Seizures/drug therapy
  • Term Birth
  • Treatment Outcome

Cite this

Maartens, I. A., Wassenberg, T., Buijs, J., Bok, L., de Kleine, M. J. K., Katgert, T., & Andriessen, P. (2012). Neurodevelopmental outcome in full-term newborns with refractory neonatal seizures. Acta Paediatrica, 101(4), e173-e178. https://doi.org/10.1111/j.1651-2227.2011.02528.x
Maartens, Imke A ; Wassenberg, Tessa ; Buijs, Jan ; Bok, Levinus ; de Kleine, Martin J.K. ; Katgert, Titia ; Andriessen, Peter. / Neurodevelopmental outcome in full-term newborns with refractory neonatal seizures. In: Acta Paediatrica. 2012 ; Vol. 101, No. 4. pp. e173-e178.
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abstract = "AIM: This retrospective study describes the prognosis of full-term newborns with refractory neonatal seizures, comparing the need for treatment with two versus three or more antiepileptic drugs.METHODS: We reviewed our database (January 2002-December 2007) to include newborns with refractory neonatal seizures and abnormal electroencephalogram. Group A consisted of 17 newborns with two antiepileptic drugs. Group B consisted of 29 newborns with three or more antiepileptic drugs. Outcome was determined at 2 years of age using the Dutch Bayley Scales of Infant Development or a neurodevelopmental classification scheme.RESULTS: Group A and group B were comparable regarding to a variety of demographic and aetiologic factors. Thirteen newborns died before 2 years of age and one was lost to follow-up. Normal development at 2 years of age was found in 50{\%} and 5{\%} for group A and B, respectively. Severe neurodevelopmental delay at 2 years of age was found in 30{\%} and 68{\%} for group A and B, respectively.CONCLUSION: The number of antiepileptic drugs probably reflects increased seizure burden and is--in that way--related to poor outcome. This may be useful information for early prediction of adverse neurological outcome in the first days of life.",
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Maartens, IA, Wassenberg, T, Buijs, J, Bok, L, de Kleine, MJK, Katgert, T & Andriessen, P 2012, 'Neurodevelopmental outcome in full-term newborns with refractory neonatal seizures', Acta Paediatrica, vol. 101, no. 4, pp. e173-e178. https://doi.org/10.1111/j.1651-2227.2011.02528.x

Neurodevelopmental outcome in full-term newborns with refractory neonatal seizures. / Maartens, Imke A; Wassenberg, Tessa; Buijs, Jan; Bok, Levinus; de Kleine, Martin J.K.; Katgert, Titia; Andriessen, Peter.

In: Acta Paediatrica, Vol. 101, No. 4, 04.2012, p. e173-e178.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Maartens, Imke A

AU - Wassenberg, Tessa

AU - Buijs, Jan

AU - Bok, Levinus

AU - de Kleine, Martin J.K.

AU - Katgert, Titia

AU - Andriessen, Peter

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N2 - AIM: This retrospective study describes the prognosis of full-term newborns with refractory neonatal seizures, comparing the need for treatment with two versus three or more antiepileptic drugs.METHODS: We reviewed our database (January 2002-December 2007) to include newborns with refractory neonatal seizures and abnormal electroencephalogram. Group A consisted of 17 newborns with two antiepileptic drugs. Group B consisted of 29 newborns with three or more antiepileptic drugs. Outcome was determined at 2 years of age using the Dutch Bayley Scales of Infant Development or a neurodevelopmental classification scheme.RESULTS: Group A and group B were comparable regarding to a variety of demographic and aetiologic factors. Thirteen newborns died before 2 years of age and one was lost to follow-up. Normal development at 2 years of age was found in 50% and 5% for group A and B, respectively. Severe neurodevelopmental delay at 2 years of age was found in 30% and 68% for group A and B, respectively.CONCLUSION: The number of antiepileptic drugs probably reflects increased seizure burden and is--in that way--related to poor outcome. This may be useful information for early prediction of adverse neurological outcome in the first days of life.

AB - AIM: This retrospective study describes the prognosis of full-term newborns with refractory neonatal seizures, comparing the need for treatment with two versus three or more antiepileptic drugs.METHODS: We reviewed our database (January 2002-December 2007) to include newborns with refractory neonatal seizures and abnormal electroencephalogram. Group A consisted of 17 newborns with two antiepileptic drugs. Group B consisted of 29 newborns with three or more antiepileptic drugs. Outcome was determined at 2 years of age using the Dutch Bayley Scales of Infant Development or a neurodevelopmental classification scheme.RESULTS: Group A and group B were comparable regarding to a variety of demographic and aetiologic factors. Thirteen newborns died before 2 years of age and one was lost to follow-up. Normal development at 2 years of age was found in 50% and 5% for group A and B, respectively. Severe neurodevelopmental delay at 2 years of age was found in 30% and 68% for group A and B, respectively.CONCLUSION: The number of antiepileptic drugs probably reflects increased seizure burden and is--in that way--related to poor outcome. This may be useful information for early prediction of adverse neurological outcome in the first days of life.

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KW - Prognosis

KW - Retrospective Studies

KW - Seizures/drug therapy

KW - Term Birth

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DO - 10.1111/j.1651-2227.2011.02528.x

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Maartens IA, Wassenberg T, Buijs J, Bok L, de Kleine MJK, Katgert T et al. Neurodevelopmental outcome in full-term newborns with refractory neonatal seizures. Acta Paediatrica. 2012 Apr;101(4):e173-e178. https://doi.org/10.1111/j.1651-2227.2011.02528.x