Neurocognitive and executive functioning in adult survivors of congenital heart disease

L. Klouda, W.J. Franklin (Corresponding author), A. Saraf, D.R. Parekh, D.D. Schwartz

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Abstract

Objective: Congenital heart disease (CHD) can affect the developing central nervous system, resulting in neurocognitive and behavioral deficits. Preoperative neurological abnormalities as well as sequelae of the open heart operations required to correct structural abnormalities of the heart contribute to these deficits. There are few studies examining the neurocognitive functioning of adults with CHD. This study sought to investigate multiple domains of neurocognitive functioning in adult survivors of CHD who had childhood cardiac surgery with either moderate or severe disease complexity. Design: A total of 48 adults (18–49 years of age) who had undergone cardiac surgery for CHD prior to five years of age participated in the study. CHD severity was classified as moderate or severe according to the 32nd Bethesda Guidelines. A computerized battery of standardized neurocognitive tests (CNS-Vital Signs), a validated rating scale of executive functioning, and demographic questionnaires were administered. Results: There were no significant differences between the moderate CHD group and normative data on any cognitive measure. In contrast, the severe CHD group differed from norms in multiple domains: psychomotor speed, processing speed, complex attention, reaction time, and on the overall neurocognitive index. Number of surgeries was strongly related to worse executive functioning. There was no association between age at first surgery or time since last surgery and neuropsychological functioning. Number of surgeries was also unrelated to neurocognitive test performance. Conclusions: Patients with severe CHD performed significantly worse on measures of processing speed, attention, and executive functioning. These findings may be useful in the long-term care of adults with congenital heart disease.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalCongenital Heart Disease
Volume12
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Keywords

  • congenital cardiac surgery
  • congenital heart defect
  • executive function
  • neurocognitive outcomes
  • Psychomotor Performance
  • Severity of Illness Index
  • Cross-Sectional Studies
  • Humans
  • Middle Aged
  • Attention
  • Survivors/psychology
  • Male
  • Reaction Time
  • Cognition
  • Case-Control Studies
  • Neuropsychological Tests
  • Young Adult
  • Cardiac Surgical Procedures
  • Heart Defects, Congenital/diagnosis
  • Time Factors
  • Adolescent
  • Adult
  • Female
  • Executive Function

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