Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatos

R.E.A. Tjon Pian Gi, G.B. Halmos, B.M. Hemel, van, E.R. Heuvel, van den, B.F.A.M. Laan, van der, B.E.C. Plaat, F.G. Dikkers

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28 Citations (Scopus)

Abstract

Objectives/Hypothesis: Recurrent respiratory papillomatosis (RRP) is a rare, benign, wart-like disease for which no curative treatment exists. The goal of treatment is total surgical removal of the epithelial lesions to keep the airway open and the voice sufficient. Therefore, it is essential to visualize all papillomatous lesions. The present study aims to evaluate the sensitivity of additional use of narrow band imaging (NBI) in detecting RRP during microlaryngoscopy. Study Design: Prospective study. Methods: Between January 2011 and July 2011, patients with RRP underwent systematic inspection during microlaryngoscopy using conventional white light (WL) immediately followed by inspection with NBI. Consensus was achieved about the number of lesions and number of RRP suspect lesions. All lesions were subsequently excised and sent for histopathological examination. Results: Eighty-six excisional biopsies were taken in 24 microlaryngoscopies performed in 14 RRP patients. Eleven out of the 13 additional biopsies taken, induced by the second inspection with NBI, proved to be papillomata after histopathological examination. The sensitivity increased from 80% with WL up to 97% with WL + NBI (P <.01), whereas the specificity remained poor (32% and 28%, respectively). Conclusions: NBI is an additional diagnostic tool in increasing the sensitivity of visualizing papillomata during microlaryngoscopy. Keywords: Endoscopy; microlaryngoscopy; imaging; narrow band imaging; laryngeal papillomatosis; papilloma; recurrent respiratory papillomatosis; Level of Evidence: 4
Original languageEnglish
Pages (from-to)1826-1830
JournalThe Laryngoscope
Volume122
Issue number8
DOIs
Publication statusPublished - Aug 2012
Externally publishedYes

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Narrow Band Imaging
Papilloma
Light
Biopsy
Warts
Endoscopy
Recurrent respiratory papillomatosis
Prospective Studies
Therapeutics

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Tjon Pian Gi, R. E. A., Halmos, G. B., Hemel, van, B. M., Heuvel, van den, E. R., Laan, van der, B. F. A. M., Plaat, B. E. C., & Dikkers, F. G. (2012). Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatos. The Laryngoscope, 122(8), 1826-1830. https://doi.org/10.1002/lary.23344
Tjon Pian Gi, R.E.A. ; Halmos, G.B. ; Hemel, van, B.M. ; Heuvel, van den, E.R. ; Laan, van der, B.F.A.M. ; Plaat, B.E.C. ; Dikkers, F.G. / Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatos. In: The Laryngoscope. 2012 ; Vol. 122, No. 8. pp. 1826-1830.
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abstract = "Objectives/Hypothesis: Recurrent respiratory papillomatosis (RRP) is a rare, benign, wart-like disease for which no curative treatment exists. The goal of treatment is total surgical removal of the epithelial lesions to keep the airway open and the voice sufficient. Therefore, it is essential to visualize all papillomatous lesions. The present study aims to evaluate the sensitivity of additional use of narrow band imaging (NBI) in detecting RRP during microlaryngoscopy. Study Design: Prospective study. Methods: Between January 2011 and July 2011, patients with RRP underwent systematic inspection during microlaryngoscopy using conventional white light (WL) immediately followed by inspection with NBI. Consensus was achieved about the number of lesions and number of RRP suspect lesions. All lesions were subsequently excised and sent for histopathological examination. Results: Eighty-six excisional biopsies were taken in 24 microlaryngoscopies performed in 14 RRP patients. Eleven out of the 13 additional biopsies taken, induced by the second inspection with NBI, proved to be papillomata after histopathological examination. The sensitivity increased from 80{\%} with WL up to 97{\%} with WL + NBI (P <.01), whereas the specificity remained poor (32{\%} and 28{\%}, respectively). Conclusions: NBI is an additional diagnostic tool in increasing the sensitivity of visualizing papillomata during microlaryngoscopy. Keywords: Endoscopy; microlaryngoscopy; imaging; narrow band imaging; laryngeal papillomatosis; papilloma; recurrent respiratory papillomatosis; Level of Evidence: 4",
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Tjon Pian Gi, REA, Halmos, GB, Hemel, van, BM, Heuvel, van den, ER, Laan, van der, BFAM, Plaat, BEC & Dikkers, FG 2012, 'Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatos', The Laryngoscope, vol. 122, no. 8, pp. 1826-1830. https://doi.org/10.1002/lary.23344

Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatos. / Tjon Pian Gi, R.E.A.; Halmos, G.B.; Hemel, van, B.M.; Heuvel, van den, E.R.; Laan, van der, B.F.A.M.; Plaat, B.E.C.; Dikkers, F.G.

In: The Laryngoscope, Vol. 122, No. 8, 08.2012, p. 1826-1830.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatos

AU - Tjon Pian Gi, R.E.A.

AU - Halmos, G.B.

AU - Hemel, van, B.M.

AU - Heuvel, van den, E.R.

AU - Laan, van der, B.F.A.M.

AU - Plaat, B.E.C.

AU - Dikkers, F.G.

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N2 - Objectives/Hypothesis: Recurrent respiratory papillomatosis (RRP) is a rare, benign, wart-like disease for which no curative treatment exists. The goal of treatment is total surgical removal of the epithelial lesions to keep the airway open and the voice sufficient. Therefore, it is essential to visualize all papillomatous lesions. The present study aims to evaluate the sensitivity of additional use of narrow band imaging (NBI) in detecting RRP during microlaryngoscopy. Study Design: Prospective study. Methods: Between January 2011 and July 2011, patients with RRP underwent systematic inspection during microlaryngoscopy using conventional white light (WL) immediately followed by inspection with NBI. Consensus was achieved about the number of lesions and number of RRP suspect lesions. All lesions were subsequently excised and sent for histopathological examination. Results: Eighty-six excisional biopsies were taken in 24 microlaryngoscopies performed in 14 RRP patients. Eleven out of the 13 additional biopsies taken, induced by the second inspection with NBI, proved to be papillomata after histopathological examination. The sensitivity increased from 80% with WL up to 97% with WL + NBI (P <.01), whereas the specificity remained poor (32% and 28%, respectively). Conclusions: NBI is an additional diagnostic tool in increasing the sensitivity of visualizing papillomata during microlaryngoscopy. Keywords: Endoscopy; microlaryngoscopy; imaging; narrow band imaging; laryngeal papillomatosis; papilloma; recurrent respiratory papillomatosis; Level of Evidence: 4

AB - Objectives/Hypothesis: Recurrent respiratory papillomatosis (RRP) is a rare, benign, wart-like disease for which no curative treatment exists. The goal of treatment is total surgical removal of the epithelial lesions to keep the airway open and the voice sufficient. Therefore, it is essential to visualize all papillomatous lesions. The present study aims to evaluate the sensitivity of additional use of narrow band imaging (NBI) in detecting RRP during microlaryngoscopy. Study Design: Prospective study. Methods: Between January 2011 and July 2011, patients with RRP underwent systematic inspection during microlaryngoscopy using conventional white light (WL) immediately followed by inspection with NBI. Consensus was achieved about the number of lesions and number of RRP suspect lesions. All lesions were subsequently excised and sent for histopathological examination. Results: Eighty-six excisional biopsies were taken in 24 microlaryngoscopies performed in 14 RRP patients. Eleven out of the 13 additional biopsies taken, induced by the second inspection with NBI, proved to be papillomata after histopathological examination. The sensitivity increased from 80% with WL up to 97% with WL + NBI (P <.01), whereas the specificity remained poor (32% and 28%, respectively). Conclusions: NBI is an additional diagnostic tool in increasing the sensitivity of visualizing papillomata during microlaryngoscopy. Keywords: Endoscopy; microlaryngoscopy; imaging; narrow band imaging; laryngeal papillomatosis; papilloma; recurrent respiratory papillomatosis; Level of Evidence: 4

U2 - 10.1002/lary.23344

DO - 10.1002/lary.23344

M3 - Article

C2 - 22566012

VL - 122

SP - 1826

EP - 1830

JO - The Laryngoscope

JF - The Laryngoscope

SN - 0023-852X

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ER -

Tjon Pian Gi REA, Halmos GB, Hemel, van BM, Heuvel, van den ER, Laan, van der BFAM, Plaat BEC et al. Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatos. The Laryngoscope. 2012 Aug;122(8):1826-1830. https://doi.org/10.1002/lary.23344