This chapter focuses on advanced delivery of biologics including growth factors (GFs), cytokines, genes, or siRNAs using a variety of nanosized systems for different regeneration applications focusing on bone, cartilage, nervous system, and muscle regeneration strategies. Gene therapy provides permanent genetic alteration, but only transient actions of protein therapeutics can be needed for tissue regeneration applications. The limitations of biologics delivery and alternative strategies for overcoming recent problems are underlined presenting recent examples from the literature. In addition, specific targeting and cellular internalization strategies of biologies delivery for tissue regeneration are discussed for providing future perspectives to the readers in this field. Overall, it is believed that advanced nanosized delivery systems integrated with multicomponent designs will open new opportunities in delivery technologies and strategies for tissue regeneration.
|Title of host publication||Therapeutic Nanomaterials|
|Subtitle of host publication||Guler/Therapeutic Nanomaterials|
|Editors||Mustafa O. Guler, Ayse B. Tekinay|
|Publication status||Published - 16 Mar 2016|
Cinar, G., Mumcuoglu, D., Tekinay, A. B., & Guler, M. O. (2016). Nanosized delivery systems for tissue regeneration. In M. O. Guler, & A. B. Tekinay (Eds.), Therapeutic Nanomaterials: Guler/Therapeutic Nanomaterials (pp. 7-31). Wiley. https://doi.org/10.1002/9781118987483.ch2