Myocardial resistance assessed by guidewire-based pressure-temperature measurement : in vitro validation

W.H. Aarnoudse; P.M.J. van den Berg; F.N. Vosse, van de; M.C.F. Geven; M.C.M. Rutten; M.C. Turnhout, van; W.F. Fearon; B. Bruyne, de; N.H.J. Pijls

doi:10.1002/ccd.10793

Myocardial resistance assessed by guidewire-based pressure-temperature measurement : in vitro validation

W.H. Aarnoudse, P.M.J. van den Berg, F.N. Vosse, van de, M.C.F. Geven, M.C.M. Rutten, M.C. Turnhout, van, W.F. Fearon, B. Bruyne, de, N.H.J. Pijls

Research output: Contribution to journal › Article › Academic › peer-review

39 Citations (Scopus)

Abstract

By injecting a few cubic centimeters of saline into the coronary artery and using thermodilution principles, mean transit time (Tmn) of the injectate can be calculated and is inversely proportional to coronary blood ow. Because microvascular resistance equals distal coronary pressure (Pd) divided by myocardial ow, the product Pd Tmn provides an index of myocardial resistance (IMR). In this in vitro study in a physiologic model of the coronary circulation, we compared IMR to true myocardial resistance (TMR) at different degrees of myocardial resistance and at different degrees of epicardial stenosis. Absolute blood ow was varied from 42 to 203 ml/min and TMR varied from 0.39 to 1.63 dynes sec/cm5. Inverse mean transit time correlated well to absolute blood ow (R2 0.93). Furthermore, an excellent correlation was found between IMR and TMR (R2 0.94). IMR was independent on the severity of epicardial stenosis and thus speci c for myocardial resistance. Thus, using one single guidewire, both fractional ow reserve and IMR can be measured simultaneously as indexes of epicardial and microvascular disease, respectively, enabling separate assessment of both coronary arterial and microvascular disease.

Original language	English
Pages (from-to)	56-63
Journal	Catheterization and Cardiovascular Interventions
Volume	62
Issue number	1
DOIs	https://doi.org/10.1002/ccd.10793
Publication status	Published - 2004

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Aarnoudse, W. H., van den Berg, P. M. J., Vosse, van de, F. N., Geven, M. C. F., Rutten, M. C. M., Turnhout, van, M. C., Fearon, W. F., Bruyne, de, B., & Pijls, N. H. J. (2004). Myocardial resistance assessed by guidewire-based pressure-temperature measurement : in vitro validation. Catheterization and Cardiovascular Interventions, 62(1), 56-63. https://doi.org/10.1002/ccd.10793

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title = "Myocardial resistance assessed by guidewire-based pressure-temperature measurement : in vitro validation",

abstract = "By injecting a few cubic centimeters of saline into the coronary artery and using thermodilution principles, mean transit time (Tmn) of the injectate can be calculated and is inversely proportional to coronary blood ow. Because microvascular resistance equals distal coronary pressure (Pd) divided by myocardial ow, the product Pd Tmn provides an index of myocardial resistance (IMR). In this in vitro study in a physiologic model of the coronary circulation, we compared IMR to true myocardial resistance (TMR) at different degrees of myocardial resistance and at different degrees of epicardial stenosis. Absolute blood ow was varied from 42 to 203 ml/min and TMR varied from 0.39 to 1.63 dynes sec/cm5. Inverse mean transit time correlated well to absolute blood ow (R2 0.93). Furthermore, an excellent correlation was found between IMR and TMR (R2 0.94). IMR was independent on the severity of epicardial stenosis and thus speci c for myocardial resistance. Thus, using one single guidewire, both fractional ow reserve and IMR can be measured simultaneously as indexes of epicardial and microvascular disease, respectively, enabling separate assessment of both coronary arterial and microvascular disease.",

author = "W.H. Aarnoudse and {van den Berg}, P.M.J. and {Vosse, van de}, F.N. and M.C.F. Geven and M.C.M. Rutten and {Turnhout, van}, M.C. and W.F. Fearon and {Bruyne, de}, B. and N.H.J. Pijls",

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Myocardial resistance assessed by guidewire-based pressure-temperature measurement : in vitro validation. / Aarnoudse, W.H.; van den Berg, P.M.J.; Vosse, van de, F.N.; Geven, M.C.F.; Rutten, M.C.M.; Turnhout, van, M.C.; Fearon, W.F.; Bruyne, de, B.; Pijls, N.H.J.

In: Catheterization and Cardiovascular Interventions, Vol. 62, No. 1, 2004, p. 56-63.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Myocardial resistance assessed by guidewire-based pressure-temperature measurement : in vitro validation

AU - Aarnoudse, W.H.

AU - van den Berg, P.M.J.

AU - Vosse, van de, F.N.

AU - Geven, M.C.F.

AU - Rutten, M.C.M.

AU - Turnhout, van, M.C.

AU - Fearon, W.F.

AU - Bruyne, de, B.

AU - Pijls, N.H.J.

PY - 2004

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N2 - By injecting a few cubic centimeters of saline into the coronary artery and using thermodilution principles, mean transit time (Tmn) of the injectate can be calculated and is inversely proportional to coronary blood ow. Because microvascular resistance equals distal coronary pressure (Pd) divided by myocardial ow, the product Pd Tmn provides an index of myocardial resistance (IMR). In this in vitro study in a physiologic model of the coronary circulation, we compared IMR to true myocardial resistance (TMR) at different degrees of myocardial resistance and at different degrees of epicardial stenosis. Absolute blood ow was varied from 42 to 203 ml/min and TMR varied from 0.39 to 1.63 dynes sec/cm5. Inverse mean transit time correlated well to absolute blood ow (R2 0.93). Furthermore, an excellent correlation was found between IMR and TMR (R2 0.94). IMR was independent on the severity of epicardial stenosis and thus speci c for myocardial resistance. Thus, using one single guidewire, both fractional ow reserve and IMR can be measured simultaneously as indexes of epicardial and microvascular disease, respectively, enabling separate assessment of both coronary arterial and microvascular disease.

AB - By injecting a few cubic centimeters of saline into the coronary artery and using thermodilution principles, mean transit time (Tmn) of the injectate can be calculated and is inversely proportional to coronary blood ow. Because microvascular resistance equals distal coronary pressure (Pd) divided by myocardial ow, the product Pd Tmn provides an index of myocardial resistance (IMR). In this in vitro study in a physiologic model of the coronary circulation, we compared IMR to true myocardial resistance (TMR) at different degrees of myocardial resistance and at different degrees of epicardial stenosis. Absolute blood ow was varied from 42 to 203 ml/min and TMR varied from 0.39 to 1.63 dynes sec/cm5. Inverse mean transit time correlated well to absolute blood ow (R2 0.93). Furthermore, an excellent correlation was found between IMR and TMR (R2 0.94). IMR was independent on the severity of epicardial stenosis and thus speci c for myocardial resistance. Thus, using one single guidewire, both fractional ow reserve and IMR can be measured simultaneously as indexes of epicardial and microvascular disease, respectively, enabling separate assessment of both coronary arterial and microvascular disease.

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DO - 10.1002/ccd.10793

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SN - 1522-1946

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