Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem

Manon Meerman, Tom C L Bracco Gartner, Jan Willem Buikema, Sean M Wu, Sailay Siddiqi, Carlijn V C Bouten, K Jane Grande-Allen, Willem J L Suyker, Jesper Hjortnaes (Corresponding author)

Research output: Contribution to journalReview articlepeer-review

Abstract

Radiation-induced cardiovascular disease is a well-known complication of radiation exposure. Over the last few years, planning for deep space missions has increased interest in the effects of space radiation on the cardiovascular system, as an increasing number of astronauts will be exposed to space radiation for longer periods of time. Research has shown that exposure to different types of particles found in space radiation can lead to the development of diverse cardiovascular disease via fibrotic myocardial remodeling, accelerated atherosclerosis and microvascular damage. Several underlying mechanisms for radiation-induced cardiovascular disease have been identified, but many aspects of the pathophysiology remain unclear. Existing pharmacological compounds have been evaluated to protect the cardiovascular system from space radiation-induced damage, but currently no radioprotective compounds have been approved. This review critically analyzes the effects of space radiation on the cardiovascular system, the underlying mechanisms and potential countermeasures to space radiation-induced cardiovascular disease.

Original languageEnglish
Article number631985
Number of pages12
JournalFrontiers in Cardiovascular Medicine
Volume8
DOIs
Publication statusPublished - 12 Feb 2021

Bibliographical note

Copyright © 2021 Meerman, Bracco Gartner, Buikema, Wu, Siddiqi, Bouten, Grande-Allen, Suyker and Hjortnaes.

Fingerprint Dive into the research topics of 'Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem'. Together they form a unique fingerprint.

Cite this