Muscle blood volume assessment during exercise with Power Doppler Ultrasound

H.M. Heres, B.C.Y. Tchang, T. Schoots, M.C.M. Rutten, F.N. van de Vosse, R.G.P. Lopata

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Assessment of perfusion adaptation in muscle during exercise can provide diagnostic information on cardiac and endothelial diseases. Power Doppler Ultrasound (PDUS) is known for its feasibility in the non-invasive measurement of moving blood volume (MBV), a perfusion related parameter. In this study, we show how PDUS can be used to assess the MBV kinetics in muscle, before, during, and after exercise. In a volunteer study, PDUS signal was obtained continuously on the gastrocnemius muscle and rectus femoris muscle, during calf raise (N=11) and leg extension exercises (N=11), respectively. To test reproducibility, the measurements were repeated on two different days. A clear increase of PDUS signal was obtained in both exercises. MBV kinetics during leg extension and after calf raise are assessed by linear and mono-exponential fitting of the data. The reproducibility of the obtained slope and time constants of the signal increase and decay were moderate to good between measurement days, with intra-class correlations (ICC) values of 0.6 - 0.8. Future studies will focus on protocol standardization and the monitoring of muscle perfusion during whole body exercise.
Original languageEnglish
Title of host publicationUltrasonics Symposium (IUS), 2016 IEEE International, 18-21 September 2016
Place of PublicationPiscataway
PublisherInstitute of Electrical and Electronics Engineers
ISBN (Electronic)978-1-4673-9897-8
Publication statusPublished - 2016


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