Muscle blood volume assessment during exercise with Power Doppler Ultrasound

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Abstract

Assessment of perfusion adaptation in muscle during exercise can provide diagnostic information on cardiac and endothelial diseases. Power Doppler Ultrasound (PDUS) is known for its feasibility in the non-invasive measurement of moving blood volume (MBV), a perfusion related parameter. In this study, we show how PDUS can be used to assess the MBV kinetics in muscle, before, during, and after exercise. In a volunteer study, PDUS signal was obtained continuously on the gastrocnemius muscle and rectus femoris muscle, during calf raise (N=11) and leg extension exercises (N=11), respectively. To test reproducibility, the measurements were repeated on two different days. A clear increase of PDUS signal was obtained in both exercises. MBV kinetics during leg extension and after calf raise are assessed by linear and mono-exponential fitting of the data. The reproducibility of the obtained slope and time constants of the signal increase and decay were moderate to good between measurement days, with intra-class correlations (ICC) values of 0.6 - 0.8. Future studies will focus on protocol standardization and the monitoring of muscle perfusion during whole body exercise.
Original languageEnglish
Title of host publicationUltrasonics Symposium (IUS), 2016 IEEE International, 18-21 September 2016
Place of PublicationPiscataway
PublisherInstitute of Electrical and Electronics Engineers
ISBN (Electronic)978-1-4673-9897-8
DOIs
Publication statusPublished - 2016

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Doppler Ultrasonography
Blood Volume
Exercise
Muscles
Perfusion
Leg
Quadriceps Muscle
Volunteers
Heart Diseases
Skeletal Muscle

Cite this

Heres, H. M., Tchang, B. C. Y., Schoots, T., Rutten, M. C. M., van de Vosse, F. N., & Lopata, R. G. P. (2016). Muscle blood volume assessment during exercise with Power Doppler Ultrasound. In Ultrasonics Symposium (IUS), 2016 IEEE International, 18-21 September 2016 Piscataway: Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/ULTSYM.2016.7728776
Heres, H.M. ; Tchang, B.C.Y. ; Schoots, T. ; Rutten, M.C.M. ; van de Vosse, F.N. ; Lopata, R.G.P. / Muscle blood volume assessment during exercise with Power Doppler Ultrasound. Ultrasonics Symposium (IUS), 2016 IEEE International, 18-21 September 2016. Piscataway : Institute of Electrical and Electronics Engineers, 2016.
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title = "Muscle blood volume assessment during exercise with Power Doppler Ultrasound",
abstract = "Assessment of perfusion adaptation in muscle during exercise can provide diagnostic information on cardiac and endothelial diseases. Power Doppler Ultrasound (PDUS) is known for its feasibility in the non-invasive measurement of moving blood volume (MBV), a perfusion related parameter. In this study, we show how PDUS can be used to assess the MBV kinetics in muscle, before, during, and after exercise. In a volunteer study, PDUS signal was obtained continuously on the gastrocnemius muscle and rectus femoris muscle, during calf raise (N=11) and leg extension exercises (N=11), respectively. To test reproducibility, the measurements were repeated on two different days. A clear increase of PDUS signal was obtained in both exercises. MBV kinetics during leg extension and after calf raise are assessed by linear and mono-exponential fitting of the data. The reproducibility of the obtained slope and time constants of the signal increase and decay were moderate to good between measurement days, with intra-class correlations (ICC) values of 0.6 - 0.8. Future studies will focus on protocol standardization and the monitoring of muscle perfusion during whole body exercise.",
author = "H.M. Heres and B.C.Y. Tchang and T. Schoots and M.C.M. Rutten and {van de Vosse}, F.N. and R.G.P. Lopata",
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Heres, HM, Tchang, BCY, Schoots, T, Rutten, MCM, van de Vosse, FN & Lopata, RGP 2016, Muscle blood volume assessment during exercise with Power Doppler Ultrasound. in Ultrasonics Symposium (IUS), 2016 IEEE International, 18-21 September 2016. Institute of Electrical and Electronics Engineers, Piscataway. https://doi.org/10.1109/ULTSYM.2016.7728776

Muscle blood volume assessment during exercise with Power Doppler Ultrasound. / Heres, H.M.; Tchang, B.C.Y.; Schoots, T.; Rutten, M.C.M.; van de Vosse, F.N.; Lopata, R.G.P.

Ultrasonics Symposium (IUS), 2016 IEEE International, 18-21 September 2016. Piscataway : Institute of Electrical and Electronics Engineers, 2016.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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N2 - Assessment of perfusion adaptation in muscle during exercise can provide diagnostic information on cardiac and endothelial diseases. Power Doppler Ultrasound (PDUS) is known for its feasibility in the non-invasive measurement of moving blood volume (MBV), a perfusion related parameter. In this study, we show how PDUS can be used to assess the MBV kinetics in muscle, before, during, and after exercise. In a volunteer study, PDUS signal was obtained continuously on the gastrocnemius muscle and rectus femoris muscle, during calf raise (N=11) and leg extension exercises (N=11), respectively. To test reproducibility, the measurements were repeated on two different days. A clear increase of PDUS signal was obtained in both exercises. MBV kinetics during leg extension and after calf raise are assessed by linear and mono-exponential fitting of the data. The reproducibility of the obtained slope and time constants of the signal increase and decay were moderate to good between measurement days, with intra-class correlations (ICC) values of 0.6 - 0.8. Future studies will focus on protocol standardization and the monitoring of muscle perfusion during whole body exercise.

AB - Assessment of perfusion adaptation in muscle during exercise can provide diagnostic information on cardiac and endothelial diseases. Power Doppler Ultrasound (PDUS) is known for its feasibility in the non-invasive measurement of moving blood volume (MBV), a perfusion related parameter. In this study, we show how PDUS can be used to assess the MBV kinetics in muscle, before, during, and after exercise. In a volunteer study, PDUS signal was obtained continuously on the gastrocnemius muscle and rectus femoris muscle, during calf raise (N=11) and leg extension exercises (N=11), respectively. To test reproducibility, the measurements were repeated on two different days. A clear increase of PDUS signal was obtained in both exercises. MBV kinetics during leg extension and after calf raise are assessed by linear and mono-exponential fitting of the data. The reproducibility of the obtained slope and time constants of the signal increase and decay were moderate to good between measurement days, with intra-class correlations (ICC) values of 0.6 - 0.8. Future studies will focus on protocol standardization and the monitoring of muscle perfusion during whole body exercise.

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Heres HM, Tchang BCY, Schoots T, Rutten MCM, van de Vosse FN, Lopata RGP. Muscle blood volume assessment during exercise with Power Doppler Ultrasound. In Ultrasonics Symposium (IUS), 2016 IEEE International, 18-21 September 2016. Piscataway: Institute of Electrical and Electronics Engineers. 2016 https://doi.org/10.1109/ULTSYM.2016.7728776