Multivalent peptide and protein dendrimers using native chemical ligation

I. Baal, van; H. Malda; S.A. Synowsky; J.L.J. Dongen, van; T.M. Hackeng; M. Merkx; E.W. Meijer

doi:10.1002/ange.200500635

Multivalent peptide and protein dendrimers using native chemical ligation

I. Baal, van, H. Malda, S.A. Synowsky, J.L.J. Dongen, van, T.M. Hackeng, M. Merkx, E.W. Meijer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A wide variety of well-defined multivalent peptides and proteins can be made by conjugating synthetic peptides and recombinantly expressed proteins to cysteine-functionalized dendrimers using native chemical ligation (see picture). This modular approach provides access to dendrimers that are attractive both for understanding fundamental issues of multivalency in biological interactions as well as for biomedical applications.

Original language	English
Pages (from-to)	5180-5185
Number of pages	7
Journal	Angewandte Chemie
Volume	117
Issue number	32
DOIs	https://doi.org/10.1002/ange.200500635
Publication status	Published - 2005

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title = "Multivalent peptide and protein dendrimers using native chemical ligation",

abstract = "A wide variety of well-defined multivalent peptides and proteins can be made by conjugating synthetic peptides and recombinantly expressed proteins to cysteine-functionalized dendrimers using native chemical ligation (see picture). This modular approach provides access to dendrimers that are attractive both for understanding fundamental issues of multivalency in biological interactions as well as for biomedical applications.",

author = "{Baal, van}, I. and H. Malda and S.A. Synowsky and {Dongen, van}, J.L.J. and T.M. Hackeng and M. Merkx and E.W. Meijer",

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AU - Baal, van, I.

AU - Malda, H.

AU - Synowsky, S.A.

AU - Dongen, van, J.L.J.

AU - Hackeng, T.M.

AU - Merkx, M.

AU - Meijer, E.W.

PY - 2005

Y1 - 2005

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AB - A wide variety of well-defined multivalent peptides and proteins can be made by conjugating synthetic peptides and recombinantly expressed proteins to cysteine-functionalized dendrimers using native chemical ligation (see picture). This modular approach provides access to dendrimers that are attractive both for understanding fundamental issues of multivalency in biological interactions as well as for biomedical applications.

U2 - 10.1002/ange.200500635

DO - 10.1002/ange.200500635

M3 - Article

SN - 0044-8249

VL - 117

SP - 5180

EP - 5185

JO - Angewandte Chemie

JF - Angewandte Chemie

IS - 32

ER -

Multivalent peptide and protein dendrimers using native chemical ligation

Abstract

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