TY - JOUR
T1 - Multivalent choline dendrimers as potent inhibitors of pneumococcal cell wall hydrolysis
AU - Hernandez-Rocamora, V.M.
AU - Maestro, B.
AU - Waal, de, B.F.M.
AU - Morales, M.
AU - Garcia, P.
AU - Meijer, E.W.
AU - Merkx, M.
AU - Sanz, J.M.
PY - 2009
Y1 - 2009
N2 - Dendritic cell wall mimics are choline-binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline-functionalized dendrimers are potent inhibitors of these essential enzymes, with a 103-104-fold higher affinity than free choline, resulting in inhibition of autolysis and cell sepn. in bacterial cultures at low micromolar concns.
AB - Dendritic cell wall mimics are choline-binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline-functionalized dendrimers are potent inhibitors of these essential enzymes, with a 103-104-fold higher affinity than free choline, resulting in inhibition of autolysis and cell sepn. in bacterial cultures at low micromolar concns.
U2 - 10.1002/anie.200803664
DO - 10.1002/anie.200803664
M3 - Article
C2 - 19115336
SN - 0570-0833
VL - 48
SP - 948
EP - 951
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 5
ER -