Multitechnology Biofabrication: A New Approach for the Manufacturing of Functional Tissue Structures?

Miguel Castilho; Mylène de Ruijter; Stephen Beirne; Claire C. Villette; Keita Ito; Gordon G. Wallace; Jos Malda

doi:10.1016/j.tibtech.2020.04.014

Multitechnology Biofabrication: A New Approach for the Manufacturing of Functional Tissue Structures?

Miguel Castilho (Corresponding author)
, Mylène de Ruijter
, Stephen Beirne
, Claire C. Villette
, Keita Ito
, Gordon G. Wallace
, Jos Malda

Research output: Contribution to journal › Review article › peer-review

92 Citations (Scopus)

156 Downloads (Pure)

Abstract

Most available 3D biofabrication technologies rely on single-component deposition methods, such as inkjet, extrusion, or light-assisted printing. It is unlikely that any of these technologies used individually would be able to replicate the complexity and functionality of living tissues. Recently, new biofabrication approaches have emerged that integrate multiple manufacturing technologies into a single biofabrication platform. This has led to fabricated structures with improved functionality. In this review, we provide a comprehensive overview of recent advances in the integration of different manufacturing technologies with the aim to fabricate more functional tissue structures. We provide our vision on the future of additive manufacturing (AM) technology, digital design, and the use of artificial intelligence (AI) in the field of biofabrication.

Original language	English
Pages (from-to)	1316-1328
Number of pages	13
Journal	Trends in Biotechnology
Volume	38
Issue number	12
Early online date	25 May 2020
DOIs	https://doi.org/10.1016/j.tibtech.2020.04.014
Publication status	Published - Dec 2020

Funding

The authors would like to acknowledge support from the strategic alliance University Medical Center Utrecht–Utrecht University–Eindhoven University of Technology and funding from the partners of Regenerative Medicine Crossing Borders ( www.regmedxb.com ) powered by Health∼Holland, Top Sector Life Sciences & Health, ReumaNederland (LLP-12 and LLP22), the European Research Council (Grant Agreement No. 647426, 3D-JOINT ), and the Netherlands Organization for Scientific Research (Materials Driven Regeneration, 024.003.013). Funding from the Australian Research Council Centre of Excellence Scheme ( CE 140100012 ) and ARC Industrial Transformation Training Centre Scheme ( IC160100026 ) is also gratefully acknowledged. The authors would also like to thank the Australian National Fabrication Facility-Materials Node (ANFF).

Funders	Funder number
UMC Utrecht
European Union's Horizon 2020 - Research and Innovation Framework Programme	647426
European Union's Horizon 2020 - Research and Innovation Framework Programme	3D-JOINT
Australian Research Council	CE 140100012, IC160100026
Eindhoven University of Technology
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	024.003.013

Keywords

3D bioprinting
artificial intelligence
convergency of technologies
digital design
functional tissue
hybrid fabrication

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10.1016/j.tibtech.2020.04.014

1-s2.0-S0167779920301190-mainFinal published version, 2.45 MBLicence: TAVERNE

Cite this

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title = "Multitechnology Biofabrication: A New Approach for the Manufacturing of Functional Tissue Structures?",

abstract = "Most available 3D biofabrication technologies rely on single-component deposition methods, such as inkjet, extrusion, or light-assisted printing. It is unlikely that any of these technologies used individually would be able to replicate the complexity and functionality of living tissues. Recently, new biofabrication approaches have emerged that integrate multiple manufacturing technologies into a single biofabrication platform. This has led to fabricated structures with improved functionality. In this review, we provide a comprehensive overview of recent advances in the integration of different manufacturing technologies with the aim to fabricate more functional tissue structures. We provide our vision on the future of additive manufacturing (AM) technology, digital design, and the use of artificial intelligence (AI) in the field of biofabrication.",

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Multitechnology Biofabrication: A New Approach for the Manufacturing of Functional Tissue Structures?

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