Multitechnology Biofabrication: A New Approach for the Manufacturing of Functional Tissue Structures?

Miguel Castilho (Corresponding author), Mylène de Ruijter, Stephen Beirne, Claire C. Villette, Keita Ito, Gordon G. Wallace, Jos Malda

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)


Most available 3D biofabrication technologies rely on single-component deposition methods, such as inkjet, extrusion, or light-assisted printing. It is unlikely that any of these technologies used individually would be able to replicate the complexity and functionality of living tissues. Recently, new biofabrication approaches have emerged that integrate multiple manufacturing technologies into a single biofabrication platform. This has led to fabricated structures with improved functionality. In this review, we provide a comprehensive overview of recent advances in the integration of different manufacturing technologies with the aim to fabricate more functional tissue structures. We provide our vision on the future of additive manufacturing (AM) technology, digital design, and the use of artificial intelligence (AI) in the field of biofabrication.

Original languageEnglish
Pages (from-to)1316-1328
Number of pages13
JournalTrends in Biotechnology
Issue number12
Early online date25 May 2020
Publication statusPublished - Dec 2020


  • 3D bioprinting
  • artificial intelligence
  • convergency of technologies
  • digital design
  • functional tissue
  • hybrid fabrication


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