Multistep Feed-Forward Activation by Calcium in the Energy Buffered Skeletal Muscle Cell

R.G.P.M. Stiphout, van; P.J. Verhoog; N.A.W. Riel, van; H.M.M. Eikelder, ten; K. Nicolay; P.A.J. Hilbers; J.A.L. Jeneson

Multistep Feed-Forward Activation by Calcium in the Energy Buffered Skeletal Muscle Cell

R.G.P.M. Stiphout, van, P.J. Verhoog, N.A.W. Riel, van, H.M.M. Eikelder, ten, K. Nicolay, P.A.J. Hilbers, J.A.L. Jeneson

Mathematics and Computer Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

Mitochondria in skeletal muscle cells deal with large intracellular calcium oscillations.Although calcium activates mitochondrial metabolism, the net effects of these oscillations oncell energetics are mostly qualitatively known. A model has been developed to test (i) ifoscillatory behavior is transferred to cytosolic thermodynamic potential of ATP hydrolysis(DGpi), (ii) if oscillatory behavior is dampened by CK/AK buffering and (iii) if multistep feedforwardactivation improves energy homeostasis and explains the empirical sigmoidal relationbetween steady-state ATP production rate (JATPss) and the primary feedback signal controllingthis flux : cytoplasmic ADP (ADPiss) [1].

Original language	English
Title of host publication	Proceedings of the First Dutch Conference on Bio-Medical Engineering (BME 2007) 18-19 January 2007, Egmond aan zee, The Netherlands
Publication status	Published - 2007

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Stiphout, van, R. G. P. M., Verhoog, P. J., Riel, van, N. A. W., Eikelder, ten, H. M. M., Nicolay, K., Hilbers, P. A. J., & Jeneson, J. A. L. (2007). Multistep Feed-Forward Activation by Calcium in the Energy Buffered Skeletal Muscle Cell. In Proceedings of the First Dutch Conference on Bio-Medical Engineering (BME 2007) 18-19 January 2007, Egmond aan zee, The Netherlands

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title = "Multistep Feed-Forward Activation by Calcium in the Energy Buffered Skeletal Muscle Cell",

abstract = "Mitochondria in skeletal muscle cells deal with large intracellular calcium oscillations.Although calcium activates mitochondrial metabolism, the net effects of these oscillations oncell energetics are mostly qualitatively known. A model has been developed to test (i) ifoscillatory behavior is transferred to cytosolic thermodynamic potential of ATP hydrolysis(DGpi), (ii) if oscillatory behavior is dampened by CK/AK buffering and (iii) if multistep feedforwardactivation improves energy homeostasis and explains the empirical sigmoidal relationbetween steady-state ATP production rate (JATPss) and the primary feedback signal controllingthis flux : cytoplasmic ADP (ADPiss) [1].",

author = "{Stiphout, van}, R.G.P.M. and P.J. Verhoog and {Riel, van}, N.A.W. and {Eikelder, ten}, H.M.M. and K. Nicolay and P.A.J. Hilbers and J.A.L. Jeneson",

year = "2007",

language = "English",

booktitle = "Proceedings of the First Dutch Conference on Bio-Medical Engineering (BME 2007) 18-19 January 2007, Egmond aan zee, The Netherlands",

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Multistep Feed-Forward Activation by Calcium in the Energy Buffered Skeletal Muscle Cell. / Stiphout, van, R.G.P.M.; Verhoog, P.J.; Riel, van, N.A.W. et al.
Proceedings of the First Dutch Conference on Bio-Medical Engineering (BME 2007) 18-19 January 2007, Egmond aan zee, The Netherlands. 2007.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Multistep Feed-Forward Activation by Calcium in the Energy Buffered Skeletal Muscle Cell

AU - Stiphout, van, R.G.P.M.

AU - Verhoog, P.J.

AU - Riel, van, N.A.W.

AU - Eikelder, ten, H.M.M.

AU - Nicolay, K.

AU - Hilbers, P.A.J.

AU - Jeneson, J.A.L.

PY - 2007

Y1 - 2007

N2 - Mitochondria in skeletal muscle cells deal with large intracellular calcium oscillations.Although calcium activates mitochondrial metabolism, the net effects of these oscillations oncell energetics are mostly qualitatively known. A model has been developed to test (i) ifoscillatory behavior is transferred to cytosolic thermodynamic potential of ATP hydrolysis(DGpi), (ii) if oscillatory behavior is dampened by CK/AK buffering and (iii) if multistep feedforwardactivation improves energy homeostasis and explains the empirical sigmoidal relationbetween steady-state ATP production rate (JATPss) and the primary feedback signal controllingthis flux : cytoplasmic ADP (ADPiss) [1].

AB - Mitochondria in skeletal muscle cells deal with large intracellular calcium oscillations.Although calcium activates mitochondrial metabolism, the net effects of these oscillations oncell energetics are mostly qualitatively known. A model has been developed to test (i) ifoscillatory behavior is transferred to cytosolic thermodynamic potential of ATP hydrolysis(DGpi), (ii) if oscillatory behavior is dampened by CK/AK buffering and (iii) if multistep feedforwardactivation improves energy homeostasis and explains the empirical sigmoidal relationbetween steady-state ATP production rate (JATPss) and the primary feedback signal controllingthis flux : cytoplasmic ADP (ADPiss) [1].

M3 - Conference contribution

BT - Proceedings of the First Dutch Conference on Bio-Medical Engineering (BME 2007) 18-19 January 2007, Egmond aan zee, The Netherlands

ER -

Multistep Feed-Forward Activation by Calcium in the Energy Buffered Skeletal Muscle Cell

Abstract

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