Multiple sclerosis: neurofilament light chain antibodies are correlated to cerebral atrophy

M.J. Eikelenboom, A. Petzold, R.H.C. Lazeron, E. Silber, M. Sharief, E.J. Thompson, F. Barkhof, G. Giovannoni, C.H. Polman, B.M.J. Uitdehaag

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Abstract

Objective: To evaluate markers of axonal damage in CSF and serum of patients with different subtypes of MS in relation to measures of disease progression on MRI. Methods: In 51 patients with MS (21 relapsing-remitting, 20 secondary progressive, 10 primary progressive), levels of heavy and light neurofilaments (NfH and NfL) and antibodies to neurofilaments (anti-NfL and -NfH) as well as the total immunoglobulin G (IgG) were analyzed. MRI analysis included T2 hyperintense, T1 hypointense, and gadolinium enhancing lesions and markers of cerebral atrophy (ventricular and parenchymal fractions). Results: For the total group, correlations were found between the anti-NfL index and the parenchymal fraction (PF) (r = -0.51, p <0.001), T2 lesion load (r = 0.41, p <0.05), ventricular fraction (r = 0.37, p <0.05), and T1 lesion load (r = 0.37, p <0.05). For the anti-NfH index, a correlation was found with the PF (r = -0.39, p <0.05). No correlations were found between the IgG index and MRI measures. Conclusions: Intrathecal production of anti-NfL antibodies may serve as a marker of tissue damage, particularly axonal loss, in MS.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalNeurology
Volume60
Issue number2
Publication statusPublished - 28 Jan 2003
Externally publishedYes

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Intermediate Filaments
Multiple Sclerosis
Atrophy
Immunoglobulin G
Light
Antibodies
Gadolinium
Disease Progression
Anti-Idiotypic Antibodies
Serum

Cite this

Eikelenboom, M. J., Petzold, A., Lazeron, R. H. C., Silber, E., Sharief, M., Thompson, E. J., ... Uitdehaag, B. M. J. (2003). Multiple sclerosis: neurofilament light chain antibodies are correlated to cerebral atrophy. Neurology, 60(2), 219-223.
Eikelenboom, M.J. ; Petzold, A. ; Lazeron, R.H.C. ; Silber, E. ; Sharief, M. ; Thompson, E.J. ; Barkhof, F. ; Giovannoni, G. ; Polman, C.H. ; Uitdehaag, B.M.J. / Multiple sclerosis: neurofilament light chain antibodies are correlated to cerebral atrophy. In: Neurology. 2003 ; Vol. 60, No. 2. pp. 219-223.
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Eikelenboom, MJ, Petzold, A, Lazeron, RHC, Silber, E, Sharief, M, Thompson, EJ, Barkhof, F, Giovannoni, G, Polman, CH & Uitdehaag, BMJ 2003, 'Multiple sclerosis: neurofilament light chain antibodies are correlated to cerebral atrophy', Neurology, vol. 60, no. 2, pp. 219-223.

Multiple sclerosis: neurofilament light chain antibodies are correlated to cerebral atrophy. / Eikelenboom, M.J.; Petzold, A.; Lazeron, R.H.C.; Silber, E.; Sharief, M.; Thompson, E.J.; Barkhof, F.; Giovannoni, G.; Polman, C.H.; Uitdehaag, B.M.J.

In: Neurology, Vol. 60, No. 2, 28.01.2003, p. 219-223.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Eikelenboom, M.J.

AU - Petzold, A.

AU - Lazeron, R.H.C.

AU - Silber, E.

AU - Sharief, M.

AU - Thompson, E.J.

AU - Barkhof, F.

AU - Giovannoni, G.

AU - Polman, C.H.

AU - Uitdehaag, B.M.J.

PY - 2003/1/28

Y1 - 2003/1/28

N2 - Objective: To evaluate markers of axonal damage in CSF and serum of patients with different subtypes of MS in relation to measures of disease progression on MRI. Methods: In 51 patients with MS (21 relapsing-remitting, 20 secondary progressive, 10 primary progressive), levels of heavy and light neurofilaments (NfH and NfL) and antibodies to neurofilaments (anti-NfL and -NfH) as well as the total immunoglobulin G (IgG) were analyzed. MRI analysis included T2 hyperintense, T1 hypointense, and gadolinium enhancing lesions and markers of cerebral atrophy (ventricular and parenchymal fractions). Results: For the total group, correlations were found between the anti-NfL index and the parenchymal fraction (PF) (r = -0.51, p <0.001), T2 lesion load (r = 0.41, p <0.05), ventricular fraction (r = 0.37, p <0.05), and T1 lesion load (r = 0.37, p <0.05). For the anti-NfH index, a correlation was found with the PF (r = -0.39, p <0.05). No correlations were found between the IgG index and MRI measures. Conclusions: Intrathecal production of anti-NfL antibodies may serve as a marker of tissue damage, particularly axonal loss, in MS.

AB - Objective: To evaluate markers of axonal damage in CSF and serum of patients with different subtypes of MS in relation to measures of disease progression on MRI. Methods: In 51 patients with MS (21 relapsing-remitting, 20 secondary progressive, 10 primary progressive), levels of heavy and light neurofilaments (NfH and NfL) and antibodies to neurofilaments (anti-NfL and -NfH) as well as the total immunoglobulin G (IgG) were analyzed. MRI analysis included T2 hyperintense, T1 hypointense, and gadolinium enhancing lesions and markers of cerebral atrophy (ventricular and parenchymal fractions). Results: For the total group, correlations were found between the anti-NfL index and the parenchymal fraction (PF) (r = -0.51, p <0.001), T2 lesion load (r = 0.41, p <0.05), ventricular fraction (r = 0.37, p <0.05), and T1 lesion load (r = 0.37, p <0.05). For the anti-NfH index, a correlation was found with the PF (r = -0.39, p <0.05). No correlations were found between the IgG index and MRI measures. Conclusions: Intrathecal production of anti-NfL antibodies may serve as a marker of tissue damage, particularly axonal loss, in MS.

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Eikelenboom MJ, Petzold A, Lazeron RHC, Silber E, Sharief M, Thompson EJ et al. Multiple sclerosis: neurofilament light chain antibodies are correlated to cerebral atrophy. Neurology. 2003 Jan 28;60(2):219-223.