Multiple functionalities of biochemical reaction networks

M.N. Steijaert, A.M.L. Liekens, H.M.M. Eikelder, ten, P.A.J. Hilbers

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

28 Downloads (Pure)

Abstract

We consider a biological cell as a highly nterconnected network of chemical reactions, which is constituted of a large number of semi-autonomous functional modules. Depending on the global state of the network, the separate functional modules may display qualitatively different behavior. As an example, we study a conceptual network of phosphorylation cycles, for which the steady-state concentration of an output compound depends on the concentrations of two input enzymes. We show that the input-output relation depends on the expression of the proteins in the network. Hence changes in protein expression, due to changes in the global regulatory network of the cell, can change the functionality of the module. In this specific example, changed expression of two proteins is sufficient to switch between the functionalities of various logical gates.
Original languageEnglish
Title of host publicationArtificial Life XI : Proceedings of the Eleventh International Conference on Artificial Life (ALIFe XI), 5-8 August 2008, Winchester, UK
EditorsR. Watson, S. Bullock, J. Noble, M.A. Bedau
Place of PublicationUnited Kingdom, Winchester
PublisherMIT Press
Pages585-591
Publication statusPublished - 2008

Fingerprint Dive into the research topics of 'Multiple functionalities of biochemical reaction networks'. Together they form a unique fingerprint.

  • Cite this

    Steijaert, M. N., Liekens, A. M. L., Eikelder, ten, H. M. M., & Hilbers, P. A. J. (2008). Multiple functionalities of biochemical reaction networks. In R. Watson, S. Bullock, J. Noble, & M. A. Bedau (Eds.), Artificial Life XI : Proceedings of the Eleventh International Conference on Artificial Life (ALIFe XI), 5-8 August 2008, Winchester, UK (pp. 585-591). MIT Press.