Multicompartment nanoparticles formed by a heparin-mimicking block terpolymer in aqueous solutions

Mariusz Uchman; Miroslav Štěpánek; Karel Procházka; Grigoris Mountrichas; Stergios Pispas; Ilja K. Voets; Andreas Walther

doi:10.1021/ma9008115

Multicompartment nanoparticles formed by a heparin-mimicking block terpolymer in aqueous solutions

Mariusz Uchman (Corresponding author), Miroslav Štěpánek, Karel Procházka, Grigoris Mountrichas, Stergios Pispas (Corresponding author), Ilja K. Voets, Andreas Walther

Research output: Contribution to journal › Article › Academic › peer-review

57 Citations (Scopus)

Abstract

A new amphiphilic block terpolymer poly((sulfamate-carboxylate)isoprene)- block-polystyrene-block-poly (ethylene oxide), PISC₂₃₀-PS ₅₂-PE0₁₅₁, with a narrow molecular weight distribution (PDI = 1.05), was synthesized via the post polymerization reaction of the anionically prepared precursor block terpolymer polyisoprene-block-polystyrene- block-poly(ethylene oxide) with chlorosulfonyl isocyanate. The formation and structure of self-assemblies of the polyelectrolyte block terpolymer in dilute aqueous solutions were studied by static and dynamic light scattering, atomic force and cryogenic transmission electron microscopy, fluorometry, and H NMR spectroscopy. In acidic solutions, the terpolymers self-assemble into kinetically trapped multicompartment micelles, with the core consisting of discrete PS and PISC domains and PEO in the shell. If the solution pH is adjusted to the alkaline region, the multicompartment micelles undergo an irreversible transition to regular micelles, with a PS core and a mixed shell formed by PEO and PISC blocks.

Original language	English
Pages (from-to)	5605-5613
Number of pages	9
Journal	Macromolecules
Volume	42
Issue number	15
DOIs	https://doi.org/10.1021/ma9008115
Publication status	Published - 11 Aug 2009
Externally published	Yes

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title = "Multicompartment nanoparticles formed by a heparin-mimicking block terpolymer in aqueous solutions",

abstract = "A new amphiphilic block terpolymer poly((sulfamate-carboxylate)isoprene)- block-polystyrene-block-poly (ethylene oxide), PISC230-PS 52-PE0151, with a narrow molecular weight distribution (PDI = 1.05), was synthesized via the post polymerization reaction of the anionically prepared precursor block terpolymer polyisoprene-block-polystyrene- block-poly(ethylene oxide) with chlorosulfonyl isocyanate. The formation and structure of self-assemblies of the polyelectrolyte block terpolymer in dilute aqueous solutions were studied by static and dynamic light scattering, atomic force and cryogenic transmission electron microscopy, fluorometry, and H NMR spectroscopy. In acidic solutions, the terpolymers self-assemble into kinetically trapped multicompartment micelles, with the core consisting of discrete PS and PISC domains and PEO in the shell. If the solution pH is adjusted to the alkaline region, the multicompartment micelles undergo an irreversible transition to regular micelles, with a PS core and a mixed shell formed by PEO and PISC blocks.",

author = "Mariusz Uchman and Miroslav {\v S}t{\v e}p{\'a}nek and Karel Proch{\'a}zka and Grigoris Mountrichas and Stergios Pispas and Voets, {Ilja K.} and Andreas Walther",

year = "2009",

month = aug,

day = "11",

doi = "10.1021/ma9008115",

language = "English",

volume = "42",

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journal = "Macromolecules",

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T1 - Multicompartment nanoparticles formed by a heparin-mimicking block terpolymer in aqueous solutions

AU - Uchman, Mariusz

AU - Štěpánek, Miroslav

AU - Procházka, Karel

AU - Mountrichas, Grigoris

AU - Pispas, Stergios

AU - Voets, Ilja K.

AU - Walther, Andreas

PY - 2009/8/11

Y1 - 2009/8/11

N2 - A new amphiphilic block terpolymer poly((sulfamate-carboxylate)isoprene)- block-polystyrene-block-poly (ethylene oxide), PISC230-PS 52-PE0151, with a narrow molecular weight distribution (PDI = 1.05), was synthesized via the post polymerization reaction of the anionically prepared precursor block terpolymer polyisoprene-block-polystyrene- block-poly(ethylene oxide) with chlorosulfonyl isocyanate. The formation and structure of self-assemblies of the polyelectrolyte block terpolymer in dilute aqueous solutions were studied by static and dynamic light scattering, atomic force and cryogenic transmission electron microscopy, fluorometry, and H NMR spectroscopy. In acidic solutions, the terpolymers self-assemble into kinetically trapped multicompartment micelles, with the core consisting of discrete PS and PISC domains and PEO in the shell. If the solution pH is adjusted to the alkaline region, the multicompartment micelles undergo an irreversible transition to regular micelles, with a PS core and a mixed shell formed by PEO and PISC blocks.

AB - A new amphiphilic block terpolymer poly((sulfamate-carboxylate)isoprene)- block-polystyrene-block-poly (ethylene oxide), PISC230-PS 52-PE0151, with a narrow molecular weight distribution (PDI = 1.05), was synthesized via the post polymerization reaction of the anionically prepared precursor block terpolymer polyisoprene-block-polystyrene- block-poly(ethylene oxide) with chlorosulfonyl isocyanate. The formation and structure of self-assemblies of the polyelectrolyte block terpolymer in dilute aqueous solutions were studied by static and dynamic light scattering, atomic force and cryogenic transmission electron microscopy, fluorometry, and H NMR spectroscopy. In acidic solutions, the terpolymers self-assemble into kinetically trapped multicompartment micelles, with the core consisting of discrete PS and PISC domains and PEO in the shell. If the solution pH is adjusted to the alkaline region, the multicompartment micelles undergo an irreversible transition to regular micelles, with a PS core and a mixed shell formed by PEO and PISC blocks.

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U2 - 10.1021/ma9008115

DO - 10.1021/ma9008115

M3 - Article

AN - SCOPUS:68549127124

SN - 0024-9297

VL - 42

SP - 5605

EP - 5613

JO - Macromolecules

JF - Macromolecules

IS - 15

ER -

Multicompartment nanoparticles formed by a heparin-mimicking block terpolymer in aqueous solutions

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