Multicompartment nanoparticles formed by a heparin-mimicking block terpolymer in aqueous solutions

Mariusz Uchman (Corresponding author), Miroslav Štěpánek, Karel Procházka, Grigoris Mountrichas, Stergios Pispas (Corresponding author), Ilja K. Voets, Andreas Walther

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Scopus)

Abstract

A new amphiphilic block terpolymer poly((sulfamate-carboxylate)isoprene)- block-polystyrene-block-poly (ethylene oxide), PISC230-PS 52-PE0151, with a narrow molecular weight distribution (PDI = 1.05), was synthesized via the post polymerization reaction of the anionically prepared precursor block terpolymer polyisoprene-block-polystyrene- block-poly(ethylene oxide) with chlorosulfonyl isocyanate. The formation and structure of self-assemblies of the polyelectrolyte block terpolymer in dilute aqueous solutions were studied by static and dynamic light scattering, atomic force and cryogenic transmission electron microscopy, fluorometry, and H NMR spectroscopy. In acidic solutions, the terpolymers self-assemble into kinetically trapped multicompartment micelles, with the core consisting of discrete PS and PISC domains and PEO in the shell. If the solution pH is adjusted to the alkaline region, the multicompartment micelles undergo an irreversible transition to regular micelles, with a PS core and a mixed shell formed by PEO and PISC blocks.

Original languageEnglish
Pages (from-to)5605-5613
Number of pages9
JournalMacromolecules
Volume42
Issue number15
DOIs
Publication statusPublished - 11 Aug 2009
Externally publishedYes

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    Uchman, M., Štěpánek, M., Procházka, K., Mountrichas, G., Pispas, S., Voets, I. K., & Walther, A. (2009). Multicompartment nanoparticles formed by a heparin-mimicking block terpolymer in aqueous solutions. Macromolecules, 42(15), 5605-5613. https://doi.org/10.1021/ma9008115