Multi-step non-covalent synthesis

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic


Non-covalent synthesis of supramol. objects is generally based on the self-assembly of the same components or the assembly of a mixt. of different components under the adequate conditions. Solvent, temp. and concn. tune these processes. In order to create supramol. objects that cannot be formed by simple (self-)assembly, novel approaches are to be discovered, ultimately leading to multi-step non-covalent synthesis. Our progress in this new direction of supramol. chem. is illustrated with the synthesis of nano-sized dendritic objects. These water-insol. dendrimers are first supramolecularly modified in org. solvents, by which the complex becomes water-sol. Then supramol. substitution reactions have been used to connect, again in a non-covalent fashion, oligopeptides and labeling units. The scope and limitations of multi-step non-covalent synthesis will be discussed.
Original languageEnglish
Title of host publicationAbstracts of Papers, 229th ACS National Meeting
Place of PublicationSan Diego
PublisherAmerican Chemical Society
ISBN (Print)0-8412-3955-X
Publication statusPublished - 2005
Event229th ACS National Meeting - San Diego, United States
Duration: 13 Mar 200517 Mar 2005


Conference229th ACS National Meeting
Country/TerritoryUnited States
CitySan Diego


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