MRI visualization of injectable ureidopyrimidinone hydrogelators by supramolecular contrast agent labeling

M.H. Bakker; Cheyenne C.S. Tseng; H.M. Keizer; Peter R. Seevinck; H.M. Janssen; F.J. van Slochteren; Steven A.J. Chamuleau; P.Y.W. Dankers

doi:10.1002/adhm.201701139

MRI visualization of injectable ureidopyrimidinone hydrogelators by supramolecular contrast agent labeling

M.H. Bakker, Cheyenne C.S. Tseng, H.M. Keizer, Peter R. Seevinck, H.M. Janssen, F.J. van Slochteren, Steven A.J. Chamuleau, P.Y.W. Dankers

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Abstract

Information about the in vivo location, shape, degradation, or erosion rate of injected in situ gelating hydrogels can be obtained with magnetic resonance imaging (MRI). Herein, an injectable supramolecular ureidopyrimidinone-based hydrogel (UPy-PEG) is functionalized with a modified Gadolinium(III)-DOTA complex (UPy-Gd) for contrast enhanced MRI. The contrast agent is designed to supramolecularly interact with the hydrogel network to enable high-quality imaging of this hydrogel. The applicability of the approach is demonstrated with successful visualization of the Gd-labeled UPy-PEG hydrogel after targeted intramyocardial catheter injection in a pig heart.

Original language	English
Article number	1701139
Number of pages	8
Journal	Advanced Healthcare Materials
Volume	7
Issue number	11
Early online date	15 Apr 2018
DOIs	https://doi.org/10.1002/adhm.201701139
Publication status	Published - 6 Jun 2018

Keywords

MRI
catheters
gadolinium
injectable hydrogels
ureidopyrimidinone
Biocompatible Materials/chemistry
Contrast Media/chemistry
Hydrogels/chemistry
Heart/diagnostic imaging
Magnetic Resonance Imaging
Gadolinium/chemistry
Animals
Swine
Polyethylene Glycols/chemistry
Female
Pyrimidinones/chemistry

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10.1002/adhm.201701139

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title = "MRI visualization of injectable ureidopyrimidinone hydrogelators by supramolecular contrast agent labeling",

abstract = "Information about the in vivo location, shape, degradation, or erosion rate of injected in situ gelating hydrogels can be obtained with magnetic resonance imaging (MRI). Herein, an injectable supramolecular ureidopyrimidinone-based hydrogel (UPy-PEG) is functionalized with a modified Gadolinium(III)-DOTA complex (UPy-Gd) for contrast enhanced MRI. The contrast agent is designed to supramolecularly interact with the hydrogel network to enable high-quality imaging of this hydrogel. The applicability of the approach is demonstrated with successful visualization of the Gd-labeled UPy-PEG hydrogel after targeted intramyocardial catheter injection in a pig heart.",

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author = "M.H. Bakker and Tseng, {Cheyenne C.S.} and H.M. Keizer and Seevinck, {Peter R.} and H.M. Janssen and {van Slochteren}, F.J. and Chamuleau, {Steven A.J.} and P.Y.W. Dankers",

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month = jun,

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doi = "10.1002/adhm.201701139",

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AU - Bakker, M.H.

AU - Tseng, Cheyenne C.S.

AU - Keizer, H.M.

AU - Seevinck, Peter R.

AU - Janssen, H.M.

AU - van Slochteren, F.J.

AU - Chamuleau, Steven A.J.

AU - Dankers, P.Y.W.

PY - 2018/6/6

Y1 - 2018/6/6

N2 - Information about the in vivo location, shape, degradation, or erosion rate of injected in situ gelating hydrogels can be obtained with magnetic resonance imaging (MRI). Herein, an injectable supramolecular ureidopyrimidinone-based hydrogel (UPy-PEG) is functionalized with a modified Gadolinium(III)-DOTA complex (UPy-Gd) for contrast enhanced MRI. The contrast agent is designed to supramolecularly interact with the hydrogel network to enable high-quality imaging of this hydrogel. The applicability of the approach is demonstrated with successful visualization of the Gd-labeled UPy-PEG hydrogel after targeted intramyocardial catheter injection in a pig heart.

AB - Information about the in vivo location, shape, degradation, or erosion rate of injected in situ gelating hydrogels can be obtained with magnetic resonance imaging (MRI). Herein, an injectable supramolecular ureidopyrimidinone-based hydrogel (UPy-PEG) is functionalized with a modified Gadolinium(III)-DOTA complex (UPy-Gd) for contrast enhanced MRI. The contrast agent is designed to supramolecularly interact with the hydrogel network to enable high-quality imaging of this hydrogel. The applicability of the approach is demonstrated with successful visualization of the Gd-labeled UPy-PEG hydrogel after targeted intramyocardial catheter injection in a pig heart.

KW - MRI

KW - catheters

KW - gadolinium

KW - injectable hydrogels

KW - ureidopyrimidinone

KW - Biocompatible Materials/chemistry

KW - Contrast Media/chemistry

KW - Hydrogels/chemistry

KW - Heart/diagnostic imaging

KW - Magnetic Resonance Imaging

KW - Gadolinium/chemistry

KW - Animals

KW - Swine

KW - Polyethylene Glycols/chemistry

KW - Female

KW - Pyrimidinones/chemistry

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U2 - 10.1002/adhm.201701139

DO - 10.1002/adhm.201701139

M3 - Article

C2 - 29658175

SN - 2192-2640

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JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 11

M1 - 1701139

ER -

MRI visualization of injectable ureidopyrimidinone hydrogelators by supramolecular contrast agent labeling

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Keywords

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