MRI visualization of injectable ureidopyrimidinone hydrogelators by supramolecular contrast agent labeling

M.H. Bakker, Cheyenne C.S. Tseng, H.M. Keizer, Peter R. Seevinck, H.M. Janssen, F.J. van Slochteren, Steven A.J. Chamuleau, P.Y.W. Dankers

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
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Abstract

Information about the in vivo location, shape, degradation, or erosion rate of injected in situ gelating hydrogels can be obtained with magnetic resonance imaging (MRI). Herein, an injectable supramolecular ureidopyrimidinone-based hydrogel (UPy-PEG) is functionalized with a modified Gadolinium(III)-DOTA complex (UPy-Gd) for contrast enhanced MRI. The contrast agent is designed to supramolecularly interact with the hydrogel network to enable high-quality imaging of this hydrogel. The applicability of the approach is demonstrated with successful visualization of the Gd-labeled UPy-PEG hydrogel after targeted intramyocardial catheter injection in a pig heart.

Original languageEnglish
Article number1701139
Number of pages8
JournalAdvanced Healthcare Materials
Volume7
Issue number11
Early online date15 Apr 2018
DOIs
Publication statusPublished - 6 Jun 2018

Keywords

  • MRI
  • catheters
  • gadolinium
  • injectable hydrogels
  • ureidopyrimidinone
  • Biocompatible Materials/chemistry
  • Contrast Media/chemistry
  • Hydrogels/chemistry
  • Heart/diagnostic imaging
  • Magnetic Resonance Imaging
  • Gadolinium/chemistry
  • Animals
  • Swine
  • Polyethylene Glycols/chemistry
  • Female
  • Pyrimidinones/chemistry

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