Mouse myocardial first-pass perfusion MR imaging

B.F. Coolen, R.P.M. Moonen, L.E.M. Paulis, T. Geelen, K. Nicolay, G.J. Strijkers

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Abstract

A first-pass myocardial perfusion sequence for mouse cardiac MRI is presented. A segmented ECG-triggered acquisition combined with parallel imaging acceleration was used to capture the first pass of a Gd-DTPA bolus through the mouse heart with a temporal resolution of 300–400 msec. The method was applied in healthy mice (N = 5) and in mice with permanent occlusion of the left coronary artery (N = 6). Baseline semiquantitative perfusion values of healthy myocardium showed excellent reproducibility. Infarct regions revealed a significant decrease in the semiquantitative myocardial perfusion values (0.05 ± 0.02) compared to remote myocardium (0.20 ± 0.04). Myocardial areas of decreased perfusion correlated well to infarct areas identified on the delayed-enhancement scans. This protocol is a valuable addition to the mouse cardiac MRI toolbox for preclinical studies of ischemic heart disease.
Original languageEnglish
Pages (from-to)1658-1663
JournalMagnetic Resonance in Medicine
Volume64
Issue number6
DOIs
Publication statusPublished - Dec 2010

Keywords

  • mouse cardiac MRI
  • first-pass
  • perfusion
  • Gd-DTPA
  • myocardial infarction

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