Motion correction of dynamic contrast enhanced MRI of the liver

M.J.A. Jansen, W.B. Veldhuis, M.S. van Leeuwen, J.P.W. Pluim

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)


Motion correction of dynamic contrast enhanced magnetic resonance images (DCE-MRI) is a challenging task, due to changes in image appearance. In this study a groupwise registration, using a principle component analysis (PCA) based metric, is evaluated for clinical DCE MRI of the liver. The groupwise registration transforms the images to a common space, rather than to a reference volume as conventional pairwise methods do, and computes the similarity metric on all volumes simultaneously. This groupwise registration method is compared to a pairwise approach using a mutual information metric. Clinical DCE MRI of the abdomen of eight patients were included. Per patient one lesion in the liver was manually segmented in all temporal images (N=16). The registered images were compared for accuracy, spatial and temporal smoothness after transformation, and lesion volume change. Compared to a pairwise method or no registration, groupwise registration provided better alignment. In our recently started clinical study groupwise registered clinical DCE MRI of the abdomen of nine patients were scored by three radiologists. Groupwise registration increased the assessed quality of alignment. The gain in reading time for the radiologist was estimated to vary from no difference to almost a minute. A slight increase in reader confidence was also observed. Registration had no added value for images with little motion. In conclusion, the groupwise registration of DCE MR images results in better alignment than achieved by pairwise registration, which is beneficial for clinical assessment.
Original languageEnglish
Title of host publicationMedical Imaging 2017: Image Processing
EditorsElsa D. Angelini, Martin A. Styner, Elsa D. Angelini
ISBN (Print)978-1-5106-0712-5
Publication statusPublished - 2017
EventSPIE Medical Imaging 2017 - Renaissance Orlando at Sea World/Orlando, Orlando, United States
Duration: 11 Feb 201716 Feb 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceSPIE Medical Imaging 2017
Country/TerritoryUnited States


  • Dynamic contrast enhanced MRI
  • Image registration
  • Liver
  • Motion correction
  • Validation


Dive into the research topics of 'Motion correction of dynamic contrast enhanced MRI of the liver'. Together they form a unique fingerprint.

Cite this