Morphology of proliferating epithelial cellular tissue

Pranav Madhikar, Jan Åström, Björn Baumeier, Mikko Karttunen

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We investigate morphologies of proliferating cellular tissue using a newly developed numerical simulation model for mechanical cell division. The model reproduces structures of simple multi-cellular organisms via simple rules for selective division and division plane orientation. The model is applied to a bimodal mixture of stiff cells with a low growth potential and soft cells with a high growth potential. In an even mixture, the soft cells develop into a tissue matrix and the stiff cells into a dendrite-like network structure. For soft cell inclusion in a stiff cellular matrix, the soft cells develop to a fast growing tumour like structure that gradually evacuates the stiff cell matrix. With increasing inter-cell friction, the tumour growth slows down and parts of it is driven to self-inflicted cell death.
Original languageEnglish
Article number1811.07573v1
Number of pages14, e-Print Archive, Physics
Publication statusPublished - 19 Nov 2018


  • Soft matter
  • biophysical model
  • Computational Biology
  • Simulation

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