Morphine reduced perceived anger from neutral and implicit emotional expressions

Guro Løseth, Marie Eikemo, P.M. Isager, Jostein Holmgren, Bruno Laeng, Vigdis Vindenes, Trine Hjørnevik, Siri Leknes

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
1 Downloads (Pure)


The μ-opioid system modulates responses to pain and psychosocial stress and mediates non-social and social reward. In humans, the μ-opioid agonist morphine can increase overt attention to the eye-region and visual exploration of faces with neutral expressions. However, little is known about how the human μ-opioid system influences sensitivity to and appraisal of subtle and explicit cues of social threats and reward. Here, we examined the effects of selective μ-opioid stimulation on perception of anger and happiness in faces with explicit, neutral or implicit emotion expressions. Sixty-three healthy adults (32 females) attended two sessions where they received either placebo or 10 mg per oral morphine in randomised order under double-blind conditions. Based on the known μ-opioid reduction of pain and discomfort, as well as reports suggesting that the non-specific partial agonist buprenorphine or the non-specific antagonist naltrexone affect appraisal of social emotional stimuli, we hypothesised that morphine would reduce threat sensitivity and enhance perception of happy facial expressions. While overall perception of others’ happiness was unaffected by morphine treatment, morphine reduced perception of anger in stimuli with neutral and implicit expressions without affecting perception of explicit anger. This effect was statistically unrelated to gender, subjective drug effects, mood and autism trait measures. The finding that a low dose of μ-agonist reduced the propensity to perceive anger in photos with subtle facial expressions is consistent with the notion that μ-opioids mediate social confidence and reduce sensitivity to threat cues.
Original languageEnglish
Pages (from-to)123-131
Number of pages9
Publication statusPublished - May 2018


  • Adult
  • Affect/drug effects
  • Analgesics, Opioid/pharmacology
  • Anger/drug effects
  • Attention/drug effects
  • Cues
  • Double-Blind Method
  • Emotions/drug effects
  • Expressed Emotion/drug effects
  • Facial Expression
  • Facial Recognition/drug effects
  • Female
  • Happiness
  • Humans
  • Male
  • Middle Aged
  • Morphine/metabolism
  • Perception/drug effects


Dive into the research topics of 'Morphine reduced perceived anger from neutral and implicit emotional expressions'. Together they form a unique fingerprint.

Cite this