Monodisperse micro-shell structured gelatin microparticles for temporary chemoembolization

B. Kim, S.W. Han, S.-E. Choi, D. Yim, J.-H. Kim, H.M. Wyss, J.W. Kim

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
111 Downloads (Pure)

Abstract

Embolization is a nonsurgical, minimally invasive procedure that deliberately blocks a blood vessel. Although several embolic particles have been commercialized, their much wider applications have been hampered owing mainly to particle size variation and uncontrollable degradation kinetics. Herein we introduce a microfluidic approach to fabricate highly monodisperse gelatin microparticles (GMPs) with a microshell structure. For this purpose, we fabricate uniform gelatin emulsion precursors using a microfluidic technique and consecutively cross-link them by inbound diffusion of glutaraldehyde from the oil continuous phase to the suspending gelatin precursor droplets. A model micromechanic study, carried out in an artificial blood vessel, demonstrates that the extraordinary degradation kinetics of the GMPs, which stems from the microshell structure, enables controlled rupturing while exhibiting drug release under temporary chemoembolic conditions.

Original languageEnglish
Pages (from-to)386-391
Number of pages6
JournalBiomacromolecules
Volume19
Issue number2
DOIs
Publication statusPublished - 12 Feb 2018

Keywords

  • microfluidic devices
  • micromechanics
  • Drug Delivery Systems
  • hydrogels
  • Cross-Linking Reagents/chemistry
  • Emulsions/chemistry
  • Animals
  • Capsules/administration & dosage
  • Glutaral/chemistry
  • Drug Liberation
  • Mice
  • Chemoembolization, Therapeutic/methods
  • 3T3 Cells
  • Microfluidics
  • Gelatin/chemistry

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