Monitoring thoracic fluid content using bioelectrical impedance spectroscopy and Cole modeling

Silviu Dovancescu, Salvatore Saporito, Ingeborg H.F. Herold, H.H.M. Korsten, Ronald M. Aarts, Massimo Mischi

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Abstract

Heart failure is a chronic disease marked by frequenthospitalizations due to pulmonary fluid congestion. Monitoringthe thoracic fluid status may favor the detection of fluidcongestion in an early stage and enable targeted preventivemeasures. Bioelectrical impedance spectroscopy (BIS) has beenused in combination with the Cole model for monitoring bodycomposition including fluid status. The model parameters reflectintracellular and extracellular fluid volume as well as cell sizes,types and interactions. Transthoracic BIS may be a suitableapproach to monitoring variations in thoracic fluid content.The aim of this study was to identify BIS measures, which canbe derived based on the Cole model, that are sensitive to earlystages of thoracic fluid accumulation. We simulated this medicalcondition in healthy subjects by shifting a part of the whole bloodfrom the periphery towards the thorax. The redistribution ofblood was achieved non-invasively through leg compression usinginflatable leg sleeves. We acquired BIS data before, during andafter compression of the legs and examined the effect of thoracicfluid variations on parameters derived based on the Cole modeland on geometrical properties of the impedance arc. Indicatordilution measurements obtained through cardiac magneticresonance imaging were used as a reference for the changes inpulmonary fluid volume.Eight healthy subjects were included in the study. The Colemodel parameters of the study group at baseline were: R0 = 51.4 ±6.7 Ω, R∞ = 25.0 ± 7.0 Ω, fc = 49.0 ± 10.5 kHz, α = 0.687 ± 0.027, theresistances of individual fluid compartments were RE = 51.4 ± 6.7Ω, RI = 50.5 ± 22.9 Ω, the fluid distribution ratio was K = 1.1 ± 0.3,and the radius, area and depression of the arc’s center were: R =15.7 ± 1.3 Ω, XC = −8.5 ± 1.5 Ω, A = 134.0 ± 15.6 Ω2. The effect ofleg compression was a relatively small, reversible increase inpulmonary blood volume of 90 ± 57 mL. We observed significantchanges in parameters associated with intracellular, extracellularand total fluid volume (R0: -1.5 ± 0.9 %, p < 0.01; R∞: −2.1 ± 1.1, p <0.01; RI: −2.6 ± 1.6 %, p < 0.01), and in the arc’s geometricalproperties (R: -1.6 ± 1.3 %, p < 0.05; XC: −1.7 ± 1.5 %, p < 0.05, A:−2.9 ± 1.2 %, p < 0.01). K and the parameters associated withtissue structure fc and α remained stable.Transthoracic BIS is sensitive to small variations in intrathoracicblood volume, in particular the resistances of fluidcompartments and the geometric properties of the impedancearc. Taken together with previous studies, our findings suggestthat R0 may be a suitable parameter to monitor congestion. Use ofadditional parameters such as RI, K, XC, fc and α may enable thediscrimination between different types and stages of thoracic fluidaccumulation and should be the focus of future research.
Original languageEnglish
Pages (from-to)107-115
JournalJournal of Electrical Bioimpedance
Volume8
Issue number1
DOIs
Publication statusPublished - 2017

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Dielectric Spectroscopy
Acoustic impedance
Electric Impedance
Thorax
Spectroscopy
Fluids
Monitoring
Impedance Cardiography
Leg
Healthy Volunteers
Extracellular Fluid
Blood Volume
Cell Size
Cell Communication
Chronic Disease
Heart Failure
Lung
Blood

Cite this

@article{64571587895947df9ed7c20126560bd9,
title = "Monitoring thoracic fluid content using bioelectrical impedance spectroscopy and Cole modeling",
abstract = "Heart failure is a chronic disease marked by frequenthospitalizations due to pulmonary fluid congestion. Monitoringthe thoracic fluid status may favor the detection of fluidcongestion in an early stage and enable targeted preventivemeasures. Bioelectrical impedance spectroscopy (BIS) has beenused in combination with the Cole model for monitoring bodycomposition including fluid status. The model parameters reflectintracellular and extracellular fluid volume as well as cell sizes,types and interactions. Transthoracic BIS may be a suitableapproach to monitoring variations in thoracic fluid content.The aim of this study was to identify BIS measures, which canbe derived based on the Cole model, that are sensitive to earlystages of thoracic fluid accumulation. We simulated this medicalcondition in healthy subjects by shifting a part of the whole bloodfrom the periphery towards the thorax. The redistribution ofblood was achieved non-invasively through leg compression usinginflatable leg sleeves. We acquired BIS data before, during andafter compression of the legs and examined the effect of thoracicfluid variations on parameters derived based on the Cole modeland on geometrical properties of the impedance arc. Indicatordilution measurements obtained through cardiac magneticresonance imaging were used as a reference for the changes inpulmonary fluid volume.Eight healthy subjects were included in the study. The Colemodel parameters of the study group at baseline were: R0 = 51.4 ±6.7 Ω, R∞ = 25.0 ± 7.0 Ω, fc = 49.0 ± 10.5 kHz, α = 0.687 ± 0.027, theresistances of individual fluid compartments were RE = 51.4 ± 6.7Ω, RI = 50.5 ± 22.9 Ω, the fluid distribution ratio was K = 1.1 ± 0.3,and the radius, area and depression of the arc’s center were: R =15.7 ± 1.3 Ω, XC = −8.5 ± 1.5 Ω, A = 134.0 ± 15.6 Ω2. The effect ofleg compression was a relatively small, reversible increase inpulmonary blood volume of 90 ± 57 mL. We observed significantchanges in parameters associated with intracellular, extracellularand total fluid volume (R0: -1.5 ± 0.9 {\%}, p < 0.01; R∞: −2.1 ± 1.1, p <0.01; RI: −2.6 ± 1.6 {\%}, p < 0.01), and in the arc’s geometricalproperties (R: -1.6 ± 1.3 {\%}, p < 0.05; XC: −1.7 ± 1.5 {\%}, p < 0.05, A:−2.9 ± 1.2 {\%}, p < 0.01). K and the parameters associated withtissue structure fc and α remained stable.Transthoracic BIS is sensitive to small variations in intrathoracicblood volume, in particular the resistances of fluidcompartments and the geometric properties of the impedancearc. Taken together with previous studies, our findings suggestthat R0 may be a suitable parameter to monitor congestion. Use ofadditional parameters such as RI, K, XC, fc and α may enable thediscrimination between different types and stages of thoracic fluidaccumulation and should be the focus of future research.",
author = "Silviu Dovancescu and Salvatore Saporito and Herold, {Ingeborg H.F.} and H.H.M. Korsten and Aarts, {Ronald M.} and Massimo Mischi",
year = "2017",
doi = "10.5617/jeb.5611",
language = "English",
volume = "8",
pages = "107--115",
journal = "Journal of Electrical Bioimpedance",
issn = "1891-5469",
publisher = "Oslo Bioimpedance Group",
number = "1",

}

Monitoring thoracic fluid content using bioelectrical impedance spectroscopy and Cole modeling. / Dovancescu, Silviu; Saporito, Salvatore; Herold, Ingeborg H.F.; Korsten, H.H.M.; Aarts, Ronald M.; Mischi, Massimo.

In: Journal of Electrical Bioimpedance, Vol. 8, No. 1, 2017, p. 107-115.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Monitoring thoracic fluid content using bioelectrical impedance spectroscopy and Cole modeling

AU - Dovancescu, Silviu

AU - Saporito, Salvatore

AU - Herold, Ingeborg H.F.

AU - Korsten, H.H.M.

AU - Aarts, Ronald M.

AU - Mischi, Massimo

PY - 2017

Y1 - 2017

N2 - Heart failure is a chronic disease marked by frequenthospitalizations due to pulmonary fluid congestion. Monitoringthe thoracic fluid status may favor the detection of fluidcongestion in an early stage and enable targeted preventivemeasures. Bioelectrical impedance spectroscopy (BIS) has beenused in combination with the Cole model for monitoring bodycomposition including fluid status. The model parameters reflectintracellular and extracellular fluid volume as well as cell sizes,types and interactions. Transthoracic BIS may be a suitableapproach to monitoring variations in thoracic fluid content.The aim of this study was to identify BIS measures, which canbe derived based on the Cole model, that are sensitive to earlystages of thoracic fluid accumulation. We simulated this medicalcondition in healthy subjects by shifting a part of the whole bloodfrom the periphery towards the thorax. The redistribution ofblood was achieved non-invasively through leg compression usinginflatable leg sleeves. We acquired BIS data before, during andafter compression of the legs and examined the effect of thoracicfluid variations on parameters derived based on the Cole modeland on geometrical properties of the impedance arc. Indicatordilution measurements obtained through cardiac magneticresonance imaging were used as a reference for the changes inpulmonary fluid volume.Eight healthy subjects were included in the study. The Colemodel parameters of the study group at baseline were: R0 = 51.4 ±6.7 Ω, R∞ = 25.0 ± 7.0 Ω, fc = 49.0 ± 10.5 kHz, α = 0.687 ± 0.027, theresistances of individual fluid compartments were RE = 51.4 ± 6.7Ω, RI = 50.5 ± 22.9 Ω, the fluid distribution ratio was K = 1.1 ± 0.3,and the radius, area and depression of the arc’s center were: R =15.7 ± 1.3 Ω, XC = −8.5 ± 1.5 Ω, A = 134.0 ± 15.6 Ω2. The effect ofleg compression was a relatively small, reversible increase inpulmonary blood volume of 90 ± 57 mL. We observed significantchanges in parameters associated with intracellular, extracellularand total fluid volume (R0: -1.5 ± 0.9 %, p < 0.01; R∞: −2.1 ± 1.1, p <0.01; RI: −2.6 ± 1.6 %, p < 0.01), and in the arc’s geometricalproperties (R: -1.6 ± 1.3 %, p < 0.05; XC: −1.7 ± 1.5 %, p < 0.05, A:−2.9 ± 1.2 %, p < 0.01). K and the parameters associated withtissue structure fc and α remained stable.Transthoracic BIS is sensitive to small variations in intrathoracicblood volume, in particular the resistances of fluidcompartments and the geometric properties of the impedancearc. Taken together with previous studies, our findings suggestthat R0 may be a suitable parameter to monitor congestion. Use ofadditional parameters such as RI, K, XC, fc and α may enable thediscrimination between different types and stages of thoracic fluidaccumulation and should be the focus of future research.

AB - Heart failure is a chronic disease marked by frequenthospitalizations due to pulmonary fluid congestion. Monitoringthe thoracic fluid status may favor the detection of fluidcongestion in an early stage and enable targeted preventivemeasures. Bioelectrical impedance spectroscopy (BIS) has beenused in combination with the Cole model for monitoring bodycomposition including fluid status. The model parameters reflectintracellular and extracellular fluid volume as well as cell sizes,types and interactions. Transthoracic BIS may be a suitableapproach to monitoring variations in thoracic fluid content.The aim of this study was to identify BIS measures, which canbe derived based on the Cole model, that are sensitive to earlystages of thoracic fluid accumulation. We simulated this medicalcondition in healthy subjects by shifting a part of the whole bloodfrom the periphery towards the thorax. The redistribution ofblood was achieved non-invasively through leg compression usinginflatable leg sleeves. We acquired BIS data before, during andafter compression of the legs and examined the effect of thoracicfluid variations on parameters derived based on the Cole modeland on geometrical properties of the impedance arc. Indicatordilution measurements obtained through cardiac magneticresonance imaging were used as a reference for the changes inpulmonary fluid volume.Eight healthy subjects were included in the study. The Colemodel parameters of the study group at baseline were: R0 = 51.4 ±6.7 Ω, R∞ = 25.0 ± 7.0 Ω, fc = 49.0 ± 10.5 kHz, α = 0.687 ± 0.027, theresistances of individual fluid compartments were RE = 51.4 ± 6.7Ω, RI = 50.5 ± 22.9 Ω, the fluid distribution ratio was K = 1.1 ± 0.3,and the radius, area and depression of the arc’s center were: R =15.7 ± 1.3 Ω, XC = −8.5 ± 1.5 Ω, A = 134.0 ± 15.6 Ω2. The effect ofleg compression was a relatively small, reversible increase inpulmonary blood volume of 90 ± 57 mL. We observed significantchanges in parameters associated with intracellular, extracellularand total fluid volume (R0: -1.5 ± 0.9 %, p < 0.01; R∞: −2.1 ± 1.1, p <0.01; RI: −2.6 ± 1.6 %, p < 0.01), and in the arc’s geometricalproperties (R: -1.6 ± 1.3 %, p < 0.05; XC: −1.7 ± 1.5 %, p < 0.05, A:−2.9 ± 1.2 %, p < 0.01). K and the parameters associated withtissue structure fc and α remained stable.Transthoracic BIS is sensitive to small variations in intrathoracicblood volume, in particular the resistances of fluidcompartments and the geometric properties of the impedancearc. Taken together with previous studies, our findings suggestthat R0 may be a suitable parameter to monitor congestion. Use ofadditional parameters such as RI, K, XC, fc and α may enable thediscrimination between different types and stages of thoracic fluidaccumulation and should be the focus of future research.

U2 - 10.5617/jeb.5611

DO - 10.5617/jeb.5611

M3 - Article

VL - 8

SP - 107

EP - 115

JO - Journal of Electrical Bioimpedance

JF - Journal of Electrical Bioimpedance

SN - 1891-5469

IS - 1

ER -