Molecular underpinnings of enzalutamide resistance

S. Prekovic, T. van den Broeck, S. Linder, M. E. van Royen, A. B. Houtsmuller, F. Handle, S. Joniau, W. Zwart, F. Claessens

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

Prostate cancer (PCa) is among the most common adult malignancies, and the second leading cause of cancer-related death in men. As PCa is hormone dependent, blockade of the androgen receptor (AR) signaling is an effective therapeutic strategy for men with advanced metastatic disease. The discovery of enzalutamide, a compound that effectively blocks the AR axis and its clinical application has led to a significant improvement in survival time. However, the effect of enzalutamide is not permanent, and resistance to treatment ultimately leads to development of lethal disease, for which there currently is no cure. This review will focus on the molecular underpinnings of enzalutamide resistance, bridging the gap between the preclinical and clinical research on novel therapeutic strategies for combating this lethal stage of prostate cancer.

Original languageEnglish
Pages (from-to)R545-R557
Number of pages13
JournalEndocrine-related cancer
Volume25
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018

Keywords

  • abiraterone
  • AKR3C1
  • androgen receptor
  • autophagy
  • cancer
  • enzalutamide
  • glycolysis
  • hexosamine biosynthesis
  • IL-6
  • mCRPC
  • mutations
  • prostate cancer
  • resistance
  • Wnt
  • Humans
  • Drug Resistance, Neoplasm
  • Phenylthiohydantoin/analogs & derivatives

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